publications
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| + | ====== Research Publications ====== | ||
| + | ^ # ^ Authors | ||
| + | |~~=row()~~.| Wigler, M.H. and Weinstein, I.B. | 1975 | A preparative method for obtaining enucleated mammalian cells. Biochemical and Biophysical Research Commun. 63 : 669-674. PMID: 1169063 | {{: | ||
| + | |~~=row()~~.| Wigler, M.H., Ford, J.P. and Weinstein, I.B. | 1975 | Glucocorticoid inhibition of fibrinolytic activity production by tumor cells. | ||
| + | |~~=row()~~.| Wigler, M.H. and Weinstein, I.B. | 1976 | A tumor promoter induces plasminogen activator. Nature 259: 232-233. PMID: 1250353 | {{: | ||
| + | |~~=row()~~.| Wigler, M.H. and Axel, R. | 1976 | Nucleosomes in metaphase chromosomes. Nucleic Acids Res. 3: 1463-1472. PMC343005| {{: | ||
| + | |~~=row()~~.| Wigler, M.H., Silverstein, | ||
| + | |~~=row()~~.| Weinstein, I.B. and Wigler, M. | 1977 | Cell culture studies provide new information on tumour promoters. Nature 270: 659-690. | {{: | ||
| + | |~~=row()~~.| Pellicer, A., Wigler, M., Axel, R. and Silverstin, S. | 1978 | The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell 14: 133-141. PMID: 208776 | {{: | ||
| + | |~~=row()~~.| Wigler, M., DeFeo, D. and Weinstien, I.B. | 1978 | Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. Cancer Res. 38: 1434-1437. PMID: 639070 | {{: | ||
| + | |~~=row()~~.| Wigler, M., Pellicer, A., Silverstein, | ||
| + | |~~=row()~~.| Wigler, M., Pellicer, A., Silverstein, | ||
| + | |~~=row()~~.| Wigler, M., Sweet, R., Sim, G.K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, | ||
| + | |~~=row()~~.| Wold, B., Wigler, M., Lacy, E., Maniatis, T., Silverstein, | ||
| + | |~~=row()~~.| Wigler, M., Perucho, M., Kurtz, D., Dana, S., Pellicer, A., Axel, R. and Silverstein, | ||
| + | |~~=row()~~.| Perucho, M., Hanahan, D., Lipsich, L. and Wigler, M. | 1980 | Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature 285: 207. PMID: 6246445 | {{: | ||
| + | |~~=row()~~.| Perucho, M., Hanahan, D. and Wigler, M. | 1980 | Genetic and physical linkage of exogenous sequences in transformed cells. Cell 22: 309-317. PMID: 6253083 | {{: | ||
| + | |~~=row()~~.| Hanahan, D., Lane, D., Lipsich, L., Wigler, M. and Botchan, M. | 1980 | Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell 21: 127-139. PMID: 6250708 | {{: | ||
| + | |~~=row()~~.| Perucho, M. and Wigler, M. | 1981 | Linkage and expression of foreign DNA in cultured animal cells. Cold Spring Harbor Symp. Quant. Biol., 45: 829-838. PMID: 6942952 | {{: | ||
| + | |~~=row()~~.| Wigler, M., Levy, D. and Perucho, M. | 1981 | The somatic replication of DNA methylation. Cell 24: 33-40. PMID: 6263490 | {{: | ||
| + | |~~=row()~~.| Wigler, M.H. | 1981 | The inheritance of methylation patterns in vertebrates. | ||
| + | |~~=row()~~.| Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J. and Wigler, M. | 1981 | Human-tumor-derived cell lines contain common and different transforming genes. Cell 27: 467-476. PMID: 6101201 | {{: | ||
| + | |~~=row()~~.| Goldfarb, M., Shimizu, K., Perucho, M. and Wigler, M. | 1982 | Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature 296: 404-409. PMID: 7063039 | {{: | ||
| + | |~~=row()~~.| Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., Wigler, M. | 1982 | Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature, 300: 762-765. PMID: 7177195 | {{: | ||
| + | |~~=row()~~.| Shimizu, K., Goldfarb, M., Perucho, M. Wigler, M., | 1983 | Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc. Natl. Acad. Sci., USA, 80: 383-387. PMID: 6300838 | {{: | ||
| + | |~~=row()~~.| Shimizu, K., Goldfarb, M., Suard, Y., Perucho, M., Li, Y., Kamata, T., Feramisco, J., Stavnezer, E., Fogh, J. and Wigler, M. | 1983 | Three human transforming genes are related to the viral ras oncogenes. Proc. Natl. Acad. Sci., USA 80: 2112-2116. PMID: 6300838 | {{: | ||
| + | |~~=row()~~.| Fasano, O., Taparowsky, E., Fiddes, J., Wigler, M. and Goldfarb, M. | 1983 | Sequence and structure of the coding regions of the human H- ras -1 gene from T24 bladder carcinoma cells. | ||
| + | |~~=row()~~.| Kwoh, T.J., Zipser, D. and Wigler, M. | 1983 | Mutational analysis of the cloned chicken thymidine kinase gene. J. Mol. Appl. Genetics, 2: 191-200. PMID: 6875426 | {{: | ||
| + | |~~=row()~~.| Barker, D., McCoy, M., Weinberg, R., Goldfarb, M., Wigler, M., Burt, R., Gardner, E. and White, R. | 1983 | A test of the role of two oncogenes in an inherited predisposition to colon cancer. | ||
| + | |~~=row()~~.| Taparowsky, E., Shimizu, K., Goldfarb M., and Wigler M., | 1983 | Structure and activation of the N- ras gene. Cell, 34: 581-586. PMID: 6616621 | {{: | ||
| + | |~~=row()~~.| Shimizu, K., Birnbaum, D., Ruley, M.A., Fasano, O., Suard, Y, Edlund, L., Taparowsky, E., Goldfarb, M. and Wigler, M. | 1983 | The structure of the Ki- ras gene of the human lung carcinoma cell line Calu-1. | ||
| + | |~~=row()~~.| Ryan, J., Barker, P.E., Shimizu, K., Wigler, M., and Ruddle, F.H. | 1983 | Chromosomal assignment of a family of human oncogenes. Proc. Natl. Acad. Sci., USA 80: 4460-4463. PMID: 6576347 | {{: | ||
| + | |~~=row()~~.| Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J., and Wigler, M. | 1984 | Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell, 36: 607-612. PMID: 6365329 | {{: | ||
| + | |~~=row()~~.| Fasano, O., Aldrich, T., Tamanoi, F., Taparowsky, E., Furth, M., and Wigler, M. | 1984 | Analysis of the transforming potential of the human H- ras genes by random mutagenesis. Proc. Natl. Acad. Sci., 81: 4008-4012. PMID: 6308118 | {{: | ||
| + | |~~=row()~~.| Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J. and Wigler, M. | 1984 | Genetic analysis of yeast RAS1 and RAS2 genes. Cell, 37: 437-445. PMID: 6327067 | {{: | ||
| + | |~~=row()~~.| Fasano, O., Birnbaum, D., Edlund, L., Fogh, J. and Wigler, M. | 1984 | New human transforming genes detected by a tumorigenicity assay. Molecular and Cellular Biology, 4 : 1695-1705. PMID: 6092933 | {{: | ||
| + | |~~=row()~~.| Tamanoi, F., Walsh, M., Kataoka, T. and Wigler, M. | 1984 | A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proc. Natl. Acad. Sci. USA 81: 6924-6928. PMID: 6438624 | {{: | ||
| + | |~~=row()~~.| Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., and Wigler, M. | 1985 | Functional homology of mammalian and yeast RAS genes. Cell, 40: 19-26. PMID: 2981628 | {{: | ||
| + | |~~=row()~~.| Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K., and Wigler, M. | 1985 | In yeast, RAS proteins are controlling elements of the adenylate cyclase. Cell, 40: 27-36. PMID: 2981630 | {{: | ||
| + | |~~=row()~~.| Gross, M., Sweet, R., Sathe, G., Yokoyama, S., Fasano, O., Goldfarb, M., Wigler, M., Rosenberg, M. | 1985 | Purification and characterization of human H- RAS proteins produced in E . coli . Molecular Cellular Biology, 5: 1015-1024. PMID: 3923330 | {{: | ||
| + | |~~=row()~~.| Broek, D., Samily, N., Fasano, O., Fujiyama, A., Tamanoi, F., Northup, J., and Wigler, M. | 1985 | Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins. Cell, 41: 763-769. PMID: 3891097 | {{: | ||
| + | |~~=row()~~.| Kataoka, T., Broek, D. and Wigler, M | 1985 | DNA sequence and characterization of the S . cerevisiae gene encoding adenylate cyclase. Cell, 43 : 493-505. PMID: 2934138 | {{: | ||
| + | |~~=row()~~.| Birchmeier, C., Broek, D. and Wigler, M. | 1985 | RAS proteins can induce meiosis in Xenopus oocytes. Cell, 43: 615-621. PMID: 2416466 | {{: | ||
| + | |~~=row()~~.| Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka T. and Wigler, M. | 1985 | Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposium on Quantative Biology, Volume L, pp. 721-725. PMID: 3007012 | {{: | ||
| + | |~~=row()~~.| Young, D., Waitches, G., Birchmeier, C., Fasano, O. and Wigler, M. | 1986 | Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell, 45: 711-719. PMID: 3708691 | {{: | ||
| + | |~~=row()~~.| Birchmeier, C., Birnbaum, D., Waitches, G., Fasano, O. and Wigler, M. | 1986 | Characterization of an activated human ros gene. Molecular Cellular Biology, 6: 3109-3116. PMID: 3785223 | {{: | ||
| + | |~~=row()~~.| Powers, S., Michaelis, S., Broek D., Anna-A., S.S., Field, J., Herskowitz, I. and Wigler, M. | 1986 | RAM , a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a -factor. Cell, 47: 413-422. PMID: 3533274 | {{: | ||
| + | |~~=row()~~.| Sass, P., Field, J., Nikawa, J., Toda, T. and Wigler, M. | 1986 | Cloning and characterization of the high affinity cAMP phosphodiesterase of S . cerevisiae . Proc. Natl. Acad. Sci., 83: 9303-9307. PMID: 3025832 | {{: | ||
| + | |~~=row()~~.| Birchmeier, C., Young, D. and Wigler, M. | 1986 | Characterization of two new human oncogenes. | ||
| + | |~~=row()~~.| Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S. and Wigler, M. | 1987 | The S . cerevisiae CDC25 gene product regulates the RAS /adenylate cyclase pathway. Cell, 48: 789-799. PMID: 3545497 | {{: | ||
| + | |~~=row()~~.| Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McMullen, B., Murwitz, M., Krebs, E.G. and Wigler, M. | 1987 | Cloning and characterization of BCY1 , a locus encoding a regulatory subunit of the cyclic AMP dependent protein kinase in Saccharomyces cerevisiae. Molecular Cellular Biology, 7: 1371-1377. PMID: 3037314 | {{: | ||
| + | |~~=row()~~.| Field, J., Broek, D., Kataoka, T., and Wigler, M. | 1987 | Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Molecular Cellular Biology, 7: 2128-2133. PMID: 3299060 | {{: | ||
| + | |~~=row()~~.| Rabin, M., Birnbaum, D., Young, D., Birchmeier, C., Wigler, M. and Ruddle, F. | 1987 | Human ROS1 and MAS1 oncogenes are located in regions of chromosome 6 associated with tumor-specific rearrangements. | ||
| + | |~~=row()~~.| Johnson, K.E., Cameron, S., Toda, T., Wigler, M. and Zoller, M. | 1987 | Expression in Escherichia coli of BCY1 , the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae . J. Biological Chemistry 262: 8636-8642. PMID: 3036817 | {{: | ||
| + | |~~=row()~~.| Toda, T., Cameron, S., Sass, P., M. Zoller and Wigler, M. | 1987 | Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP dependent protein kinase. Cell, 50: 277-287. PMID: 3036373 | {{: | ||
| + | |~~=row()~~.| Birchmeier, C., Sharma, S. and Wigler, M. | 1987 | Expression and rearrangement of the ros1 gene in human glioblastoma cells. Proc. Natl. Acad. Sci., 84: 9270-9274. PMID: 2827175 | {{: | ||
| + | ||~~=row()~~.| Nikawa, J., Sass, P. and Wigler, M. | 1987 | Cloning and characterization of the low affinity cyclic AMP phosphodiestrase gene of S. cerevisiae . Molecular and Cellular Biology, 7: 3629-3636. PMID: 2824992 | {{: | ||
| + | |~~=row()~~.| Nikawa, J., Cameron, S., Toda, T., Ferguson, K.M., and Wigler, M. | 1987 | Rigorous feedback control of cAMP levels in S. cerevisiae . Genes and Development, | ||
| + | |~~=row()~~.| Toda, T., Broek, D., Field, J., Michaeli, T., Cameron, S., Nikawa, J., Sass, P., Birchmeier, C., Powers, S. and Wigler, M. | 1987 | Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae. Oncogene and Cancer, S.A. Aaronson et al., (eds). Japan Sci. Soc. Press, Tokyo/VNU Sci. Press, pp. 253-260. PMID: 3290050 | {{: | ||
| + | |~~=row()~~.| Levin, L.R., Kuret, J., Johnson, K.E., Powers, S., Cameron, S., Michaeli, M., Wigler, M. and Zoller, M. | 1988 | A mutation in the catalytic subunit of the cAMP-dependent protein kinase that disrupts regulation. Science, 240: 68-70. PMID: 2832943 | {{: | ||
| + | |~~=row()~~.| Cameron, S., Levin, L., Zoller, M. and Wigler, M. | 1988 | cAMP-Independent control of sporulation, | ||
| + | |~~=row()~~.| Toda, T., Cameron, S., Sass, P and Wigler, M. | 1988 | SCH9 , a gene of S. cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP dependent protein kinase catalytic Subunits . Genes and Development, | ||
| + | |~~=row()~~.| Field, J., Nikawa, J., Broek, D., MacDonald, B., Rodgers, L., Wilson, I.A., Lerner, R.A. and Wigler, M. | 1988 | Purification of a RAS -responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Molecular and Cellular Biology, 8: 2159-2165. PMID: 2455217 | {{: | ||
| + | |~~=row()~~.| Young, D., O' | ||
| + | |~~=row()~~.| Wigler, M., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J., and Ferguson, K. | 1988 | Studies of RAS function in the yeast S. Cerevisiae . Cold Spring Harbor Symposium, vol. LIII, pages 649-655. PMID: 3076094 | {{: | ||
| + | |~~=row()~~.| Powers, S., O' | ||
| + | |~~=row()~~.| Colicelli, J., Birchmeier, C., Michaeli, T., O' | ||
| + | |~~=row()~~.| Sharma, S., Birchmeier, C., Nikawa, J., O' | ||
| + | |~~=row()~~.| Michaeli, T., Field, J., Ballester, R., O' | ||
| + | |~~=row()~~.| Ballester, R., Michaeli, T., Ferguson, K., Xu, H-P., McCormick, F. and Wigler, M. | 1989 | Genetic analysis of mammalian GAP expressed in yeast. Cell 59: 681-686. PMID: 2684416 | {{: | ||
| + | |~~=row()~~.| Young, D., Riggs, M., Field, J., Vojtek, A., Broek, D., and Wigler, M. | 1989 | The adenylyl cyclase gene from schizosaccharomyces pombe. Proc. Natl. Acad. Sci., 86: 7989-7993. | {{: | ||
| + | |~~=row()~~.| Field, J. Xu, H-P, Michaeli, T., Ballester, R., Sass, P., Wigler, M., Colicelli, J. | 1990 | Mutations of the adenylyl Cyclase gene that block RAS function in Saccharomyces Cerevisiae. Science, 247: 464-467. PMID: 2405488 | {{: | ||
| + | |~~=row()~~.| Field, J., Vojtek, A., Ballester, R., Bolger, G., Colicelli, J., Ferguson, K., Gerst, J., Kataoka, T., Michaeli, T., Powers, S., Riggs, M., Rodgers, L., Wieland, I., Wheland, B. and Wigler, M. | 1990 | Cloning and characterization of CAP , the Saccharomyces cerevisiae gene encoding the 70 kDa adenylyl cyclase associated protein. Cell, 61 : 319-327. | {{: | ||
| + | |~~=row()~~.| Weiland, I., Bolger, G., Asouline, G. and Wigler, M. | 1990 | A method for difference cloning: Gene amplification following subtractive hybridization. Proc. Natl. Acad. Sci., 87 : 2720-2724. PMID: 2138783 | {{: | ||
| + | |~~=row()~~.| Colicelli, J., Field, J., Ballester, R., Chester, N., Young, D., and Wigler, M. | 1990 | Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Mol. Cell. Biol., 10: 2539-2543. PMID: 2111437 | {{: | ||
| + | |~~=row()~~.| Birchmeier, C., O' | ||
| + | |~~=row()~~.| Wigler, M. | 1990 | GAPs in understanding Ras. Nature, 346: 696-7. PMID: 2201920 | {{: | ||
| + | |~~=row()~~.| Xu, H.-P., Riggs, M., Rodgers, L., and Wigler, M. | 1990 | A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. Nucl. Acid Res. 18: 5304. PMID: 2205842 | {{: | ||
| + | |~~=row()~~.| Xu, H-P., Wang, Y., Riggs, M., Rodgers, L. and Wigler, M. | 1990 | Biological activity of the mammalian RAP genes in Yeast. Cell Regulation, 1: 763-769. PMID: 1983087 | {{: | ||
| + | |~~=row()~~.| Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M. and Collins, F. | 1990 | The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. | ||
| + | |~~=row()~~.| Gerst, J., Ferguson, K., Vojtek, A., Wigler, M. and Field, J. | 1991 | CAP: A bifunctional component of the S. cerevisiae adenylyl cyclase complex. Mol. Cell. Biol., 11: 1248-1257. PMID: 1996090 | {{: | ||
| + | |~~=row()~~.| Kawamukai, M., Ferguson, K., Wigler, M. and Young, D. | 1991 | Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regulation, 2: 155-164. PMID: 1863602 | {{: | ||
| + | |~~=row()~~.| Colicelli, J., Birchmeier, C., Rodgers, L., Riggs, M. and Wigler, M. | 1991 | Expression of three mammalian cDNAs which interfere with RAS function in S. cerevisiae. Proc. Natl. Acad. Sci. USA, 88: 2913-2917. PMID: 1849280 | {{: | ||
| + | |~~=row()~~.| Young, D., O' | ||
| + | |~~=row()~~.| Wang, Y., Xu, H.-P., Riggs, M., Rodgers, L. and Wigler, M. | 1991 | Byr2 , an S. pombe gene encoding a protein kinase capable of partial phenotypic suppression of ras1 - strains. Mol. Cell. Biol., 11: 3554-3563. PMID: 1883874 | {{: | ||
| + | |~~=row()~~.| Wang, Y., Boguski, M., Riggs, M., Rodgers, L. and Wigler, M. | 1991 | Sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation, 2: 453-465. PMID: 2046669 | {{: | ||
| + | |~~=row()~~.| Daar, I., Nebreda, A.R., Yew, N., Sass, P., Paules, R., Santos, E., Wigler, M. and Vande Woude, G.F. | 1991 | The ras oncoprotein and M-phase activity. Science, 253: 74-76. PMID: 1829549 | {{: | ||
| + | |~~=row()~~.| Vojtek, A., Haarer, B., Field, J., Gerst, J., Pollard, T.D., Brown, S. and Wigler, M. | 1991 | Evidence for a functional link between profilin and CAP in the yeast Saccharomyces cerevisiae . Cell, 66: 497-505. PMID: 1868547 | {{: | ||
| + | |~~=row()~~.| Xu, H.-P., Jung V., Riggs M., Rodgers L. and Wigler M. | 1992 | A gene encoding a protein with seven zinc finger domains which acts on the sexual differentiation pathways of Schizosaccharomyces pombe. | ||
| + | |~~=row()~~.| Gerst, J., Rodgers L., Riggs M. and Wigler M. | 1992 | SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/ | ||
| + | |~~=row()~~.|Kawamukai, | ||
| + | |~~=row()~~.| Shibuya, E.K., Polverino, A.J., Chang, E., Wigler, M. and Ruderman, J.V. | 1992 | Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc. Natl. Acad. Sci. USA, 89: 9831-9835. PMID: 1384061 | {{: | ||
| + | |~~=row()~~.| Andersen, L.B., Ballester, R., Marchuk, D.A. Chang, E., Gutmann, D.H., Saulino, A.M., Camonis, J., Wigler, M. and Collins, F.S. | 1993 | A conserved alternative splice in the von Recklinghausen neurofibromatosis ( NF1 ) gene produces two neurofibromin isoforms, both with GAP activity. Mol. Cell. Biol. 13: 487-495. PMID: 8437860 | {{: | ||
| + | |~~=row()~~.| Gutmann, D.H., Boguski, M., Marchuk, D., Wigler, M., Collins, F.S. and Ballester, R. | 1993 | Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. | ||
| + | |~~=row()~~.| Michaeli, T., Bloom, T., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J., and Wigler, M. | 1993 | Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase deficient S. cerevisiae . J. Biological Chemistry, 268 : 12925-12932. PMID: 8438152 | {{: | ||
| + | |~~=row()~~.| Neiman, A.M., Stevenson, B.J., Xu, H-P., Sprague, G.F. Jr., Herskowitz, I., Wigler, M., and Marcus, S. | 1993 | Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol. Biol. of the Cell 4: 107-120. PMID: 8443406 | {{: | ||
| + | |~~=row()~~.| Lisitsyn, N., Lisitsyn, N. and Wigler, M. | 1993 | Cloning the differences between two complex genomes. Science 259: 946-951. PMID: 8438152 | {{: | ||
| + | |~~=row()~~.| Van Aelst, L., Barr, M., Marcus, S., Polverino, A. and Wigler, M. | 1993 | Complex formation between RAS and RAF and other protein kinases. Proc. Natl. Acad. Sci. USA, 90 : 6213-6217. PMID: 8327501 | {{: | ||
| + | |~~=row()~~.| Chardin, P., Camonis, J.H., Gale, N.W., Van Aelst, L., Schlessinger, | ||
| + | |~~=row()~~.| Bolger, G., Michaeli, T., Martins, T., St. John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M. and Ferguson, K. | 1993 | A family of human phosphodiesterases homologous to the Dunce learning and memory gene of Drosophila melanogaster are potential targets for anti-depressant drugs. Molecular and Cellular Biology, 13: 6558-6571. PMID: 8413254 | {{: | ||
| + | |~~=row()~~.| Ohlmeyer, M.H.J., Swanson, M.N., Dillard, L.W., Reader, J.C., Asouline, G., Kobayashi, R., Wigler, M., Still, W.C. | 1993 | Complex synthetic chemical libraries indexed with molecular tags. Proc. Natl. Acad. Sci. USA, 90: 10922-10926. PMID: 7504286 | {{: | ||
| + | |~~=row()~~.| Lisitsyn, N.A., Segre, J.A., Kusumi, K., Lisitsyn, N.M., Nadeau, J.H., Frankel, W.N., Wigler, M. and Landers, E.S. | 1994 | Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nature Genetics, 6: 57-63. PMID: 8136836 | {{: | ||
| + | |~~=row()~~.| Xu, Hao-Peng, White, M., Marcus, S. and Wigler, M. | 1994 | Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe . Molecular and Cellular Biology, 14: 50-58. PMID: 8264618 | {{: | ||
| + | |~~=row()~~.| Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M. and Broek, D. | 1994 | Two types of ras mutants that dominantly interfere with activators of RAS. Mol. Cell. Biol. 14: 3707-3718. PMID: 8196614 | {{: | ||
| + | |~~=row()~~.| Marcus, S., Barr, M., Polverino, A., and Wigler, M. | 1994 | Complexes between STE5 and components of the yeast pheromone-responsive MAP kinase module. | ||
| + | |~~=row()~~.| Chang, E., Barr, M., Wang, Y., Jung, V., Xu, H.-P., and Wigler, M. | 1994 | Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell, 79: 131-141. PMID: 7923372 | {{: | ||
| + | |~~=row()~~.| Lisitsyn, N.A., Lisitsina, N.M., Dalbagni, G., Barker, P., Sanches, C.A. Gnarra, J., Linehan, W.M. Reid, B.J. and Wigler, M. | 1995 | Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc. Natl. Acad. Sci. USA, 92: 151-155. PMID: 7816807 | {{: | ||
| + | |~~=row()~~.| White, M., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. and Wigler, M. | 1995 | Multiple RAS functions can contribute to mammalian cell transformation. Cell, 80: 533-541. PMID: 7867061 | {{: | ||
| + | |~~=row()~~.| Jung, V., Chen, Li, Hofmann, S.L., Wigler, M., Powers, S. | 1995 | Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block attachment and palmitoylation of Ras proteins. Mol. Cel. Biol. 15: 1333-1342. PMID: 7532279 | {{: | ||
| + | |~~=row()~~.| Van Aelst, L., White, M. and Wigler, M. | 1994 | Ras partners. | ||
| + | |~~=row()~~.| Lisitsyn, N.A., Leach, F.S., Vogelstein, B. and Wigler, M. | 1995 | Detection of genetic loss in tumors by representational difference analysis. Cold Spring Harbor Symposium on Quantative Biology, Volume 59: pp. 585-587. PMID: 7587116 | {{: | ||
| + | |~~=row()~~.| Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M.H., Wigler, M. | 1995 | Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast, Schizosaccharomyces pombe . Proc. Natl. Acad. Sci. USA, 92: 6180-6184. PMID: 7597098 | {{: | ||
| + | |~~=row()~~.| Joneson, T., White, M.A., Wigler, M.H. and Bar-Sagi, D. | 1996 | Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271: 810-812. PMID: 8628998 | {{: | ||
| + | |~~=row()~~.| Thiagalingam, | ||
| + | |~~=row()~~.| Khosravi-Far, | ||
| + | |~~=row()~~.| Barr, M.M., Tu, H., Van Aelst, L., Wigler, M. | 1996 | Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Mol. Cell. Biol. 16: 5597-5603. PMID: 8816472 | {{: | ||
| + | |~~=row()~~.| White, M.A., Vale, T., Camonis, J.H., Schaefer, E., Wigler, M.H. | 1996 | A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. | ||
| + | |~~=row()~~.| Xu, H.-P., Yanak, B.L., Wigler, M.H., and Gorin, M.B. | 1996 | New polymorphic markers in the vicinity of the pearl locus on mouse Chromosome 13. Mammalian Genome, 7: 16-19. | {{: | ||
| + | |~~=row()~~.| Li, J., Yen, C., Liaw, D., Podsypanina, | ||
| + | |~~=row()~~.| Myers, M.P., Stolarov, J.P., Eng, C., Li, J., Wang, S.I., Wigler, M., Parsons, R. and Tonks, N.K. | 1997 | P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. | ||
| + | |~~=row()~~.| Tu, H., Barr, M., Dong, D.L. and Wigler, M. | 1997 | Multiple regulatory domains on the Byr2 protein kinase. Mol. Cell. Biol., 17: 5876-5887. PMID: 9315645 | {{: | ||
| + | |~~=row()~~.| Hamaguchi, M., O' | ||
| + | |~~=row()~~.| Lucito, R., Nakamura, M., West, J.A., Han, Y., Chin, K., Jensen, K., McCombie, R., Gray, J.W., and Wigler, M. | 1998 | Genetic analysis using genomic representations. Proc.Natl.Acad.Sci.USA 95: 4487-4492. PMCID:22516 | {{: | ||
| + | |~~=row()~~.| Webb, C.P., Van Aelst, L., Wigler, M.H. and Vande Woude, G.F. | 1998 | Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc. Natl. Acad. Sci. USA 95: 8773-8778. PMCID: PMC21152 | {{: | ||
| + | |~~=row()~~.| Myers, M., Pass, I., Batty, I.H., Van der Kaay, J., Stolarov, J.P., Hemmings, B.A., Wigler, M.H., Downes, C.P., Tonks, N.K. | 1998 |The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl. Acad. Sci. USA, 95: 13513-13518. PMCID: PMC24850 | {{: | ||
| + | |~~=row()~~.| Tu, H. and Wigler, M. | 1999 | Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol. Cell. Biol., 19: 602-611. PMID: 9858584 | {{: | ||
| + | |~~=row()~~.| Dong, D.L., Liu, R., Sherlock, R., Wigler, M., Nestler, P.H. | 1999 | Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxy-terminus. Chem. & Biol., 6: 133-141. PMID: 10074468 | {{: | ||
| + | |~~=row()~~.| Lucito, R., West, J., Reiner, A., Alexander, J., Esposito, D., Mishra, B., Powers, S., Norton, L., and Wigler, M. | 2000 | Detecting gene copy number fluctuations in tumor cells by microarray analyis of genomic representations. | ||
| + | |~~=row()~~.| Wen, S., Stolarov, J., Myers, M.P., Su, J.D., Wigler, M.H., Tonks, N.K., and Durden, D.L. | 2001 | PTEN controls tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA, 98: 4622-4627. PMCID: PMC31884 | {{: | ||
| + | |~~=row()~~.| Casey, W., Mishra, B. and Wigler, M. | 2001 | Placing probes along the genome using pairwise distance data. Algorithms in Bioinformatics, | ||
| + | |~~=row()~~.| Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G.J., Wigler, M. and Mittal, V. | 2001 | Design of a retroviral-mediated ecdysone inducible system an its application to the expression profiling of the PTEN tumor suppressor. Proc. Natl. Acad. Sci., 98: 13043-13048. PMCID: 60821 | {{: | ||
| + | |~~=row()~~.| Scheffzek, K., Grünewald, P., Wohlgemuth, S., Kabsch, W., Tu, H., Wigler, M., Wittinghofer, | ||
| + | |~~=row()~~.| Wigler, M. and Mishra, B. | 2002 | Wild by Nature. Science, 296: 1408-1408. PMID: 12029116 | {{: | ||
| + | |~~=row()~~.| Hamaguchi, M., Meth, J.L., von Klitzing, C. Wei, W., Esposito, D., Rodgers, L. Walsh, T., Welch, P., King, M-C. and Wigler, M.H. | 2002 | DBC2, a candidate for a tumor suppressor gene involved in breast cancer Proc. Natl. Acad. Sci., USA 99: 13647-13652. PMCID: PMC129730 | {{: | ||
| + | |~~=row()~~.| Mu, D., Chen, L., Zhang, X., See, L-H., Koch, C.M., Yen, C., Tong, J.J., Spiegel, L., Nguyen, K.C.Q., Servoss, A., Peng, Y., Pei, L., Marks, J.R., Lowe, S., Hoey, T., Jan, L.Y., McCombie, W.R., Wigler, M.H., Powers, S. | 2003 | Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3: 297-302. PMID: 12676587 | {{: | ||
| + | |~~=row()~~.| Lucito, R., Healy, J., Alexander, J., Reiner, A., Esposito, D., Chi, M., Rodgers, L., Brady, A., Sebat, J., Troge, J., West, J., Rostan, S., Nguyen, K.C.Q., Powers, S., Ye, K.Q., Olshen, A., Venkatraman, | ||
| + | |~~=row()~~.| Healy, J., Thomas, E., Schwartz, J.T. and Wigler, M. | 2003 | Annotating large genomes with exact word matches. Genome Research 13: 2306-2315. PMCID: PMC403711 | {{: | ||
| + | |~~=row()~~.| Thomas, E.E., Srebro, N., Sebat, J., Navin, N., Healy, J., Mishra, B., and Wigler, M. | 2004 | Distribution of short, paired duplications in mammalian genomes. Proc. Natl. Acad. Sci., USA, 101: 10349-10354. PMCID: PMC478600 | {{: | ||
| + | |~~=row()~~.| Sebat, J., Muthuswamy, L., Troge, J., Alexander, J., Young, J., Lundin, P., Maner, S., Massa, H., Walker, M., Chi, M., Navin, N., Lucito, R., Healy, J., Hicks, J., Ye, K., Reiner, A., Gilliam, T.C., Trask, B., Patterson, N., Zetterberg, A., Wigler, M. | 2004 | Large-Scale Copy Number Polymorphism in the Human Genome. Science, 305: 525-528. PMID: 15273396 | {{: | ||
| + | |~~=row()~~.| Olshen, A., Venkatraman, | ||
| + | |~~=row()~~.| Daruwala, R.-S, Rudra, A., Ostrer, H., Lucito, R., Wigler, M. and Mishra, B. | 2004 | A versatile statistical analysis algorithm to detect genome copy number variation. Proc. Natl. Acad. Sci., 101: 16292-16297. PMCID: 528962 | {{: | ||
| + | |~~=row()~~.| Jobanputra, V., Sebat, J., Chung, W., Anyane-Yeboa, | ||
| + | |~~=row()~~.| West, J., Healy, J., Casey, W., Mishra, B., and Wigler, M. | 2006 | Validation of S. Pombe Sequence Assembly by Micro-Array Hybridization. Journal of Computational Biology 13: 1-20. PMID: 16740623 | {{: | ||
| + | |~~=row()~~.| Lakshmi, B., Hall, I.M., Egan, C., Alexander, J., Leotta, A., Healy, J., Zender, L., Spector, M., Xue, W., Lowe, S.W., Wigler, M. and Lucito, R. | 2006 | Mouse genomic Representational Oligonucleotide Microarray Analysis: detection of copy number variations in normal and tumor. Proc. Natl. Acad. Sci. USA 103: 11234-11239. PMCID: 1544071 | {{: | ||
| + | |~~=row()~~.| Navin, N., Grubor, V., Hicks, J., Leibu, E., Thomas, E., Troge, J., Riggs, M., Lundin, P., Maner, lS., Sebat, J., Zetterberg, A. and Wigler, M. | 2006 | Prober: Oligonucleotide FISH probe design software. Bioinformatics, | ||
| + | |~~=row()~~.| Zender, L., Spector, M.S., Xue, W., Flemming, P., Cardon-Cardo, | ||
| + | |~~=row()~~.| Hicks, J., Krasnitz, | ||
| + | |~~=row()~~.| Pelham, R.J., Rodgers, L., Hall, I., Lucito, R., Nquyen, K.C.Q., Navin, N., Hicks, J., Mu, D., Powers, S., Wigler, M. and Botstein, M. | 2006 | Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc. Natl. Acad. Sci. USA 103: 19848-19853. PMCID: 1698871 | {{: | ||
| + | |~~=row()~~.| Sebat, J., Lakshmi, B., Malhotra, D., Lese-Martin, | ||
| + | |~~=row()~~.| Zhao, X., Leotta, A., Qiu, S., Kustanovich, | ||
| + | |~~=row()~~.| Egan, C.M., Sridhar, S., Wigler, M., Hall, I.M. | 2007 | Recurrent DNA copy number variation in the laboratory mouse. Nat. Genet., 39: 1384-1389. PMID: 17965714 | {{: | ||
| + | |~~=row()~~.| Lucito, R., Suresh, S., Walter, K., Pandey, A., B. Lakshmi, Krasnitz, A., Sebat, J., Wigler, M., Klein, A.P., Brune, K., Palmisano, E., Maitra, A., Goggins, M., and Hruban, R.H. | 2007 | Copy-Number Variants in Patients with a Strong Family History of Pancreatic Cancer. Cancer Biol Ther. 6(10) 1592-9. PMCID: 17912030 | {{: | ||
| + | |~~=row()~~.| Alarcon, M., Abrahams, B.S., Stone, J.L., Duvall, J.A., Perederiy, J.V., Bomar,J.M., Sebat, J., Wigler, M., Martin, C.L., Ledbetter, D.H., Nelson, S.F., Cantor, R.M., Geschwind, D.H. | 2008 | Linkage, association, | ||
| + | |~~=row()~~.| Xue, W., Krasnitz, A., Lucito, R., Sordella, R., VanAelst, L., Cordon-Cardo, | ||
| + | |~~=row()~~.| Grubor, V., Krasnitz, A., Troge, J.E., Meth,J.L., Lakshmi, B., Kendall, J.T., Yamrom, B., Alex, G., Pai, D., Navin, N., Hufnagel, L.A., Lee, Y-H., Cook, K., Allen, S., Rai, K.R., Damle, R.N., Calissano, C., Chiorazzi, N., Wigler, M. and Esposito, D. | 2008 | Novel genomic alterations and clonal evolution in Chronic Lymphosytic Leukemia revealed by Representational Oligonucleotide Microarray Analysis (ROMA). Blood, 113: 1294-1303. PMCID: 18922857 | {{: | ||
| + | |~~=row()~~.| Zender, L., Xue, W., Zuber, J., Semighini, C.P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J.M., Schirmacher, | ||
| + | |~~=row()~~.| Hodges, E., Smith, A.D., Kendall, J., Xuan, Z., Ravi, K., Rooks, M., Zhang, M.Q., Ye, K., Bhattacharjee, | ||
| + | |~~=row()~~.| Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. | 2009 | Functional Identification of tumor-suppressor genes through an in vivo RNA interference screen in a muse lymphoma mode. Cancer Cell. 16:324-35. PMCID: 2829755 | {{: | ||
| + | |~~=row()~~.| Navin, N., Krasnitz, A., Rodgers, R., Cook, K., Meth, J., Kendall, J., Riggs, M., Eberling, Y., Troge, J., Grubor, V., Levy, D., Lundin, P., Månér, S., Zetterberg, A., Hicks, J. and Wigler, M. | 2010 | Inferring tumor progression from genomic heterogeneity. Genome Research, 20: 68-80. PMCID: 2798832. | {{: | ||
| + | |~~=row()~~.| Russnes, H.G., Moen Vollan, H.K., Lingjærde, O.C., Krasnitz, A., Lundin, P., Naume, B., Sørlie, T., Borgen, E., Rye., I.H., Langerød, A., Chin, S-F., Teschendorff, | ||
| + | |~~=row()~~.| Kamalakaran, | ||
| + | |~~=row()~~.| Navin, N., Kendall, J., Troge, J., Andrews, P., Rodgers, L., McIndoo, J., Cook, K., Stepansky, A., Levy, D., Esposito, D., Muthuswamy, L., Krasnitz, A., McCombie, R., Hicks, J., Wigler, M. | 2011 | Tumor evolution inferred by single cell sequencing. Nature, 472: 90-94. PMCID: 21399628 | {{: | ||
| + | |~~=row()~~.| Horev, G., Ellegood, J., Lerch, J.P., Son, Y.E., Muthuswamy, L., Vogel, H., Krieger, A.M., Buja, A., Henkelman, R.M., Wigler, M., Mills, A.A. | 2011 | Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc. Natl. Acad. Sci., USA, 108: 17076-17081. PMCID: 3193230 | {{: | ||
| + | |~~=row()~~.| Levy, D., Ronemus, M., Yamrom, B., Lee, Y-H., Leotta, A., Kendall, J., Marks, S., Lakshmi, B., Pai, D., Ye, K., Buja, A., Krieger, A., Yoon, S., Troge, J., Rodgers, L., Iossifov, I., Wigler, M. | 2011 | Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron, 70: 886-897. PMCID: 21658582 | {{: | ||
| + | |~~=row()~~.| Gilman, S.R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., and Vitkup, D. | 2011 | Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron 70, 898-907. PMCID: 3607702 | {{: | ||
| + | |~~=row()~~.| Lee, Y-H., Ronemus, M., Kendall, J., Lakshmi, B., Leotta, A., Levy, D., Esposito, D., Grubor, V., Ye, K., Wigler, M., and Yamrom, B. | 2012 | Reducing system noise in copy number data using principal components of self-self hybridizations. Proc. Natl. Acad. Sci., USA, 109: E103-E110. PMCID: 3271883 | {{: | ||
| + | |~~=row()~~.| Baslan, T., Kendall, K., Rodgers, L., Cox, H., Riggs, R., Stepansky, A., Troge, J., Kandasamy, R., Esposito, D., B. Lakshmi, Wigler, M., Navin, N., and Hicks, J. | 2012 | Genome wide copy number analysis of single cells. Nature Protocols, 7: 1024-1041. PMCID: 5069701 | ||
| + | |~~=row()~~.| Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y-H., Narzisi, G., Leotta, A., Kendall, J., Grabowska, E., Ma, B., Marks, S., Rodgers, L., Stepansky, A., Troge, J., Andrews, Bekritsky, M., Pradhan, K., Ghiban, E., Kramer, M., Parla, J., Demeter, R., Fulton, L., Fulton, R.S., Magrini, V.J., Ye, K., Darnell, J.C., Darnell, R.B., Mardis, E.R., Wilson, R.K., Schatz, M.C., McCombie, W.R., Wigler, M. | 2012 | De novo gene disruptions in children on the autistic spectrum. Neuron, 74: 285-299. PMCID: 3619976 | {{: | ||
| + | |~~=row()~~.| Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, | ||
| + | |~~=row()~~.| Stadler, Z.K., Esposito, D., Shan, S., Vijai, J., Yamrom, B., Levy, D., Lee, Y-H., Kendallo, J., Leotta, A., Ronemus, M., Hansen, N., Sarrel, K., | ||
| + | |~~=row()~~.| Wigler, M. | 2012 | Broad applications of single-cell nucleic acid analysis in biomedical research. Genome Medicine 2012, 4:79. PMCID: 3580448 | ||
| + | |~~=row()~~.| Krasnitz, A., Sun, G., Andrews, P., Wigler, M. | 2013 | Target inference from collections of genomic intervals. | ||
| + | |~~=row()~~.| Donnenberg, A.D., Hicks, J.B., Wigler, M., and Donnenberg, V.S. | 2013 | The cancer stem cell: Cell type or cell state? Cytometry, A 83, 5-7. PMCID: | ||
| + | |~~=row()~~.| Shi, J. Whyte, W.A., Zepeda-Mendoza, | ||
| + | |~~=row()~~.| Ronemus, M., Iossifov, I., Levy, D. Wigler, M. | 2014 | The role of de novo mutation in the genetics of autism spectrum disorders. Nature Reviews Genetics, 15: 133-141. | {{: | ||
| + | |~~=row()~~.| Warburton, D., Ronemus, M., Kline, J., Jobanputra, V., Williams, I., Anyane-Yeboa, | ||
| + | |~~=row()~~.| Dago, A.E., Stepansky, A., Carlsson, A., Luttgen, M., Kendall, J., Baslan, T., Kolatkar, A., Wigler, M., Bethel, K., Gross, M.E., Hicks, J., Kuhn, P. | 2014 | Rapid Phenotypic and Genomic Change in Response to Therapeutic Pressure in Prostate Cancer Inferred by High Content Analysis of Single Circulating Tumor Cells. | ||
| + | |~~=row()~~.|Narzisi, | ||
| + | |~~=row()~~.| Levy, D. and Wigler, M. | 2014 | Facilitated Sequence Counting and Assembly by Template Mutagenesis. Proc. Natl. Acad. Sci., USA, 111: E4632-4637. | ||
| + | |~~=row()~~.| Iossifov, I., O' | ||
| + | |~~=row()~~.| Rye, I.H., Ludin, P., Maner, S., Fjellda, R., Naume, B., Wigler, M., Hicks, J., Borresen-Dale, | ||
| + | |~~=row()~~.| Jayaprakash, | ||
| + | |~~=row()~~.| Baslan, T., Kendall, J., Ward, B., Cox, H., Leotta, A., Rodgers, L., Riggs, M., D’Italia, S., Sun, G., Yong, M., Miskimen, K., Gilmore, H., Dimitrova, N., Krasnitz, A., Harris, L., Wigler, M., Hicks, J. | 2015 | Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. | ||
| + | |~~=row()~~.| Garvin, T., Aboukhalil, R., Kendall, J., Baslan, T., Atwal, G.S., Hicks, J., Wigler, M., Schatz, M.C. | 2015 | Interactive analysis and quality assessment of single-cell copy-number variations. | ||
| + | |~~=row()~~.| Mukhopadhyay, | ||
| + | |~~=row()~~.| Iossifov, I., Levy, D., Allen, J., Ye, K., Ronemus, M., Lee, Y-H., Yamrom, B., Wigler, M. | 2015 | Low load for disruptive mutations in autism genes and their biased transmission. | ||
| + | |~~=row()~~.| Baslan, T., Kendall, J., Rodgers, L., Cox, H., Riggs, M., Stepansky, A., Troge, J., Ravi, K., Esposito, D., Lakshmi, B., Wigler, M., Navin, N., Hicks J. | 2016 | Corrigendum: | ||
| + | |~~=row()~~.| Wang, Z., Andrews, P., Kendall, J., Ma, B., Hakker, I., Rodgers, L., Ronemus, M., Wigler, M. and Levy, D. | 2016 | SMASH, a fragmentation and sequencing method for genomic copy number analysis. | ||
| + | |~~=row()~~.| Andrews, P.A., Iossifov, I., Kendall, J., Marks, S., Muthuswamy, L., Wang, Z., Levy, D. and Wigler, M. | 2016 | MUMdex: MUM-based structural variation detection. | ||
| + | |~~=row()~~.| Fang, H., Bergmann, E., Arora, K., Vacic, V., Zody, M., Iossifov, I., O' | ||
| + | |~~=row()~~.| Ye, K., Iossifov, I., Levy, D., Buja, A., Krieger, A., and Wigler M. | 2017 | Measuring shared variants in cohorts of discordant siblings with applications to autism. | ||
| + | |~~=row()~~.| Krasnitz, A., Kendall, J., Alexander, J., Levy, D., and Wigler, M. | 2017 | Early detection of cancer in blood using single-cell analysis: A proposal. | ||
| + | |~~=row()~~.| Alexander, J., Kendall, J., McIndoo, J., Rodgers, L., Aboukhalil, R., Levy, D., Stepansky, A., Sun, G., Riggs, M., Cox, H., Hakker, I., Nowak, D., Laze, J., Lukani, E., Srivastava, A., Gruschow, S., Yadav, S., Robinson, B., Atwal, G., Trotman, L., Lepor, H., Hicks, J., Wigler, M. and Krasnitz, A. | 2017 | Utility of single cell genomic evaluation of prostate cancer. | ||
| + | |~~=row()~~.| Buja, A., Volfovsky, N., Krieger, A., Lord, C., Lash, A.E., Wigler, M., and Iossifov, I. | 2017 | Damaging de novo mutations diminish motor skills in children on the autism spectrum. | ||
| + | |~~=row()~~.| Buja, A., Volfovsky, N., Krieger, A., Lord, C., Lash, A.E., Wigler, M., and Iossifov, I. | 2017 | Damaging mutations are associated with diminished motor skills and IQ in children on the autism spectrum. bioRxiv/ | ||
| + | |~~=row()~~.| Munoz, A., Yamrom, B., Lee, Y-h., Marks, S., Lin, K-T., Wang, Z., Krainer, A.R., Darnell, R.B., Wigler, M. and Iossifov, I. | 2017 | //De novo// indels within introns comtribute to ASD incidence. | ||
| + | |~~=row()~~.| Kumar, V., Rosembaum, J., Wang, Z., Forcier, T., Ronemus, M., Wigler, M. and Levy, D. | 2018 | Partial bisulfite conversion for unique template sequencing. | ||
| + | |~~=row()~~.| Li, S., Kendall, J., Park, S., Wang, Z., Alexander, J., Moffitt, A., Ranade, N., Danyko, C., Gegenhuber, B., Fischer, S., Robinson, B.D., Lepor, H., Tollkuhn, J., Gillis, J., Brouzes, E., Krasnitz, A., Levy, D. and Wigler, M. | 2019 | Copolymerization of single-cell nucleic acids into balls of acrylamide gel. Genome Research, 30: 49-61. | ||
| + | |~~=row()~~.| Moffitt, A.B., Spector., M.S., Andrews, P., Kendall, J., Alexander, J., Stepansky, A., Ma, B.C., Kolitz, J., Chiorazzi, N., Allen, S.L., Krasnitz, A., Wigler, M., Levy, D. and Wang, Z. | 2020 | Multiplex accurate sensitive quantitation (MASQ) with application to minimal residual disease in acute myeloid leukemia. | ||
| + | |~~=row()~~.| Chorbadjiev, | ||
| + | |~~=row()~~.| Baslan, T., Kendall, J., Volyanskyy, K., McNamara, K., Cox, H., D’Italia, S., Ambrosio, F., Riggs, M., Rodgers, L., Leotta, A., Song, J., Mao, Y., Wu, J., Shah, R., Merida, R.G., Chadalavada, | ||
| + | |~~=row()~~.| Vasudevan, A., Baruah, P.S., Smith, J.C., Wang, Z., Sayles, N.M., Andrews, P., Kendall, J., Leu, J., Chunduri, N.K., Levy, D., Wigler, M., Storchová, Z., Sheltzer, J.M. |2020| Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Dev Cell. 4: 413-428.e6. | {{: | ||
| + | |~~=row()~~.| Miyabayashi, | ||
| + | |~~=row()~~.| Yoon S, Munoz A, Yamrom B, Lee Y-h, Andrews P, Marks S, Wang Z, Reeves C, Winterkorn L, Krieger AM, Buja, A, Pradhan K. Ronemus M, Baldwin KK, Levy D, Wigler M, Iossifov I. |2021| Rates of contributory de novo mutation in high and low risk autism families. Nature Communications Biology, 4: 1026. PMCID: | ||
| + | |~~=row()~~.| Li S, Park S, Ye C, Danyko C, Wroten M, Andrews P, Wigler M, and Levy D. |2022| Targeted de novo phasing and long-range assembly by template mutagenesis. | ||
| + | |~~=row()~~.| Wang Z, Moffitt A, Andrews P, Wigler M, Levy D. |2022| Accurate measurement of microsatellite length by disrupting its tandem repeat structure. | ||
| + | |~~=row()~~.| Wroten M, Yoon S, Andrews P, Yamrom B, Ronemus M, Buja A, Krieger AM, Levy D, Ye K, Wigler M, and Iossifov I. |2023| Sharing parental genomes by siblings concordant or discordant for autism. Cell Genomics 3: 100319. PMCID: PMC10300587 | {{: | ||
| + | |~~=row()~~.| Li S, Alexander J, Kendall J, Andrews P, Rose E, Orjuela H, Park S, Podszus C, Shanley L, Ma R, Rishi A, Donoho DL, Goldberg GL, Levy D, and Wigler M. |2023| High-throughput single-nucleus hybrid sequencing reveals genome-transcriptome correlations in cancer. | ||
| + | |~~=row()~~.| Lammertse E, Li S, Kendall J, Kim C, Morris P, Ranade N, Levy D, Wigler M, Brouzes E. |2023| Magnetically functionalized hydrogels for high-throughput genomic applications. Adv Mater Technol 9: (2): | ||
| + | |~~=row()~~.| Li S, Alexander J, Kendall J, Andrews P, Rose E, Orjuela H, Park S, Podszus C, Shanley L, Ranade N, Morris P, Stauder D, Bradford D, Laster Z, Ronemus M, Rishi A, Frimer M, Ma R, Donoho DL, Goldberg GL, Wigler M, Levy D. |2025| Hybrid BAG-seq: DNA and RNA from the same single nucleus reveals interactions between genomic and transcriptomic landscapes in human tumor samples. Genome Biol. 2025 Sep 27; | ||
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