publications
Research Publications
| # | Authors | Year | Title | Notes | |
|---|---|---|---|---|---|
| . | Wigler, M.H. and Weinstein, I.B. | 1975 | A preparative method for obtaining enucleated mammalian cells. Biochemical and Biophysical Research Commun. 63 : 669-674. PMID: 1169063 | ||
| . | Wigler, M.H., Ford, J.P. and Weinstein, I.B. | 1975 | Glucocorticoid inhibition of fibrinolytic activity production by tumor cells. Cold Spring Harbor Symp. on Proteases and Biological Control, 849-856. | ||
| . | Wigler, M.H. and Weinstein, I.B. | 1976 | A tumor promoter induces plasminogen activator. Nature 259: 232-233. PMID: 1250353 | ||
| . | Wigler, M.H. and Axel, R. | 1976 | Nucleosomes in metaphase chromosomes. Nucleic Acids Res. 3: 1463-1472. PMC343005 | ||
| . | Wigler, M.H., Silverstein, S., Lee, L.S., Pellicer, A., Cheng, Y. and Axel, R. | 1977 | Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 11: 223-232. PMID: 194704 | ||
| . | Weinstein, I.B. and Wigler, M. | 1977 | Cell culture studies provide new information on tumour promoters. Nature 270: 659-690. | ||
| . | Pellicer, A., Wigler, M., Axel, R. and Silverstin, S. | 1978 | The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell 14: 133-141. PMID: 208776 | ||
| . | Wigler, M., DeFeo, D. and Weinstien, I.B. | 1978 | Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. Cancer Res. 38: 1434-1437. PMID: 639070 | ||
| . | Wigler, M., Pellicer, A., Silverstein, S. and Axel, R. | 1978 | Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell 14: 725-731. PMID: 210957 | ||
| . | Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G. and Chasin, L. | 1979 | DNA mediated transfer of the APRT locus into mammalian cells. Proc. Natl. Acad. Sci. USA 76: 1373-1376. PMID: 286319 | ||
| . | Wigler, M., Sweet, R., Sim, G.K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, S., and Axel, R. | 1979 | Transformation of mammalian cells with genes from prokaryotes and eukaryotes. Cell 16: 777-785. PMID: 222468 | ||
| . | Wold, B., Wigler, M., Lacy, E., Maniatis, T., Silverstein, S., and Axel, R. | 1979 | Introduction and expression of the rabbit ?-globin gene in mouse fibroblasts. Proc. Natl. Acad. Sci. USA 76: 56-84. PMID: 293672 | ||
| . | Wigler, M., Perucho, M., Kurtz, D., Dana, S., Pellicer, A., Axel, R. and Silverstein, S. | 1980 | Transformation of mammalian cells with an amplifiable dominant acting gene. Proc. Natl. Acad. Sci. U.S., 77: 3567. PMID: 6251468 | ||
| . | Perucho, M., Hanahan, D., Lipsich, L. and Wigler, M. | 1980 | Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature 285: 207. PMID: 6246445 | ||
| . | Perucho, M., Hanahan, D. and Wigler, M. | 1980 | Genetic and physical linkage of exogenous sequences in transformed cells. Cell 22: 309-317. PMID: 6253083 | ||
| . | Hanahan, D., Lane, D., Lipsich, L., Wigler, M. and Botchan, M. | 1980 | Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell 21: 127-139. PMID: 6250708 | ||
| . | Perucho, M. and Wigler, M. | 1981 | Linkage and expression of foreign DNA in cultured animal cells. Cold Spring Harbor Symp. Quant. Biol., 45: 829-838. PMID: 6942952 | ||
| . | Wigler, M., Levy, D. and Perucho, M. | 1981 | The somatic replication of DNA methylation. Cell 24: 33-40. PMID: 6263490 | ||
| . | Wigler, M.H. | 1981 | The inheritance of methylation patterns in vertebrates. Cell, 24: 285-286. PMID: 7195315 | ||
| . | Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J. and Wigler, M. | 1981 | Human-tumor-derived cell lines contain common and different transforming genes. Cell 27: 467-476. PMID: 6101201 | ||
| . | Goldfarb, M., Shimizu, K., Perucho, M. and Wigler, M. | 1982 | Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature 296: 404-409. PMID: 7063039 | ||
| . | Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., Wigler, M. | 1982 | Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature, 300: 762-765. PMID: 7177195 | ||
| . | Shimizu, K., Goldfarb, M., Perucho, M. Wigler, M., | 1983 | Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc. Natl. Acad. Sci., USA, 80: 383-387. PMID: 6300838 | ||
| . | Shimizu, K., Goldfarb, M., Suard, Y., Perucho, M., Li, Y., Kamata, T., Feramisco, J., Stavnezer, E., Fogh, J. and Wigler, M. | 1983 | Three human transforming genes are related to the viral ras oncogenes. Proc. Natl. Acad. Sci., USA 80: 2112-2116. PMID: 6300838 | ||
| . | Fasano, O., Taparowsky, E., Fiddes, J., Wigler, M. and Goldfarb, M. | 1983 | Sequence and structure of the coding regions of the human H- ras -1 gene from T24 bladder carcinoma cells. J. Mol. Appl. Genetics, 2: 173-180. PMID: 6308118 | ||
| . | Kwoh, T.J., Zipser, D. and Wigler, M. | 1983 | Mutational analysis of the cloned chicken thymidine kinase gene. J. Mol. Appl. Genetics, 2: 191-200. PMID: 6875426 | ||
| . | Barker, D., McCoy, M., Weinberg, R., Goldfarb, M., Wigler, M., Burt, R., Gardner, E. and White, R. | 1983 | A test of the role of two oncogenes in an inherited predisposition to colon cancer. Molecular Biology and Medicine, 1: 199-206. PMID: 6594558 | ||
| . | Taparowsky, E., Shimizu, K., Goldfarb M., and Wigler M., | 1983 | Structure and activation of the N- ras gene. Cell, 34: 581-586. PMID: 6616621 | ||
| . | Shimizu, K., Birnbaum, D., Ruley, M.A., Fasano, O., Suard, Y, Edlund, L., Taparowsky, E., Goldfarb, M. and Wigler, M. | 1983 | The structure of the Ki- ras gene of the human lung carcinoma cell line Calu-1. Nature, 304: 497-500. PMID: 6308465 | ||
| . | Ryan, J., Barker, P.E., Shimizu, K., Wigler, M., and Ruddle, F.H. | 1983 | Chromosomal assignment of a family of human oncogenes. Proc. Natl. Acad. Sci., USA 80: 4460-4463. PMID: 6576347 | ||
| . | Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J., and Wigler, M. | 1984 | Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell, 36: 607-612. PMID: 6365329 | ||
| . | Fasano, O., Aldrich, T., Tamanoi, F., Taparowsky, E., Furth, M., and Wigler, M. | 1984 | Analysis of the transforming potential of the human H- ras genes by random mutagenesis. Proc. Natl. Acad. Sci., 81: 4008-4012. PMID: 6308118 | ||
| . | Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J. and Wigler, M. | 1984 | Genetic analysis of yeast RAS1 and RAS2 genes. Cell, 37: 437-445. PMID: 6327067 | ||
| . | Fasano, O., Birnbaum, D., Edlund, L., Fogh, J. and Wigler, M. | 1984 | New human transforming genes detected by a tumorigenicity assay. Molecular and Cellular Biology, 4 : 1695-1705. PMID: 6092933 | ||
| . | Tamanoi, F., Walsh, M., Kataoka, T. and Wigler, M. | 1984 | A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proc. Natl. Acad. Sci. USA 81: 6924-6928. PMID: 6438624 | ||
| . | Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., and Wigler, M. | 1985 | Functional homology of mammalian and yeast RAS genes. Cell, 40: 19-26. PMID: 2981628 | ||
| . | Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K., and Wigler, M. | 1985 | In yeast, RAS proteins are controlling elements of the adenylate cyclase. Cell, 40: 27-36. PMID: 2981630 | ||
| . | Gross, M., Sweet, R., Sathe, G., Yokoyama, S., Fasano, O., Goldfarb, M., Wigler, M., Rosenberg, M. | 1985 | Purification and characterization of human H- RAS proteins produced in E . coli . Molecular Cellular Biology, 5: 1015-1024. PMID: 3923330 | ||
| . | Broek, D., Samily, N., Fasano, O., Fujiyama, A., Tamanoi, F., Northup, J., and Wigler, M. | 1985 | Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins. Cell, 41: 763-769. PMID: 3891097 | ||
| . | Kataoka, T., Broek, D. and Wigler, M | 1985 | DNA sequence and characterization of the S . cerevisiae gene encoding adenylate cyclase. Cell, 43 : 493-505. PMID: 2934138 | ||
| . | Birchmeier, C., Broek, D. and Wigler, M. | 1985 | RAS proteins can induce meiosis in Xenopus oocytes. Cell, 43: 615-621. PMID: 2416466 | ||
| . | Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka T. and Wigler, M. | 1985 | Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposium on Quantative Biology, Volume L, pp. 721-725. PMID: 3007012 | ||
| . | Young, D., Waitches, G., Birchmeier, C., Fasano, O. and Wigler, M. | 1986 | Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell, 45: 711-719. PMID: 3708691 | ||
| . | Birchmeier, C., Birnbaum, D., Waitches, G., Fasano, O. and Wigler, M. | 1986 | Characterization of an activated human ros gene. Molecular Cellular Biology, 6: 3109-3116. PMID: 3785223 | ||
| . | Powers, S., Michaelis, S., Broek D., Anna-A., S.S., Field, J., Herskowitz, I. and Wigler, M. | 1986 | RAM , a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a -factor. Cell, 47: 413-422. PMID: 3533274 | ||
| . | Sass, P., Field, J., Nikawa, J., Toda, T. and Wigler, M. | 1986 | Cloning and characterization of the high affinity cAMP phosphodiesterase of S . cerevisiae . Proc. Natl. Acad. Sci., 83: 9303-9307. PMID: 3025832 | ||
| . | Birchmeier, C., Young, D. and Wigler, M. | 1986 | Characterization of two new human oncogenes. Cold Spring Harbor Symposium, vol LI: 993-1000. PMID: 3472773 | ||
| . | Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S. and Wigler, M. | 1987 | The S . cerevisiae CDC25 gene product regulates the RAS /adenylate cyclase pathway. Cell, 48: 789-799. PMID: 3545497 | ||
| . | Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McMullen, B., Murwitz, M., Krebs, E.G. and Wigler, M. | 1987 | Cloning and characterization of BCY1 , a locus encoding a regulatory subunit of the cyclic AMP dependent protein kinase in Saccharomyces cerevisiae. Molecular Cellular Biology, 7: 1371-1377. PMID: 3037314 | ||
| . | Field, J., Broek, D., Kataoka, T., and Wigler, M. | 1987 | Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Molecular Cellular Biology, 7: 2128-2133. PMID: 3299060 | ||
| . | Rabin, M., Birnbaum, D., Young, D., Birchmeier, C., Wigler, M. and Ruddle, F. | 1987 | Human ROS1 and MAS1 oncogenes are located in regions of chromosome 6 associated with tumor-specific rearrangements. Oncogene Research, 1: 169-178. PMID: 3329713 | ||
| . | Johnson, K.E., Cameron, S., Toda, T., Wigler, M. and Zoller, M. | 1987 | Expression in Escherichia coli of BCY1 , the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae . J. Biological Chemistry 262: 8636-8642. PMID: 3036817 | ||
| . | Toda, T., Cameron, S., Sass, P., M. Zoller and Wigler, M. | 1987 | Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP dependent protein kinase. Cell, 50: 277-287. PMID: 3036373 | ||
| . | Birchmeier, C., Sharma, S. and Wigler, M. | 1987 | Expression and rearrangement of the ros1 gene in human glioblastoma cells. Proc. Natl. Acad. Sci., 84: 9270-9274. PMID: 2827175 | ||
| . | Nikawa, J., Sass, P. and Wigler, M. | 1987 | Cloning and characterization of the low affinity cyclic AMP phosphodiestrase gene of S. cerevisiae . Molecular and Cellular Biology, 7: 3629-3636. PMID: 2824992 | ||
| . | Nikawa, J., Cameron, S., Toda, T., Ferguson, K.M., and Wigler, M. | 1987 | Rigorous feedback control of cAMP levels in S. cerevisiae . Genes and Development, 1: 931-937. PMID: 2828175 | ||
| . | Toda, T., Broek, D., Field, J., Michaeli, T., Cameron, S., Nikawa, J., Sass, P., Birchmeier, C., Powers, S. and Wigler, M. | 1987 | Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae. Oncogene and Cancer, S.A. Aaronson et al., (eds). Japan Sci. Soc. Press, Tokyo/VNU Sci. Press, pp. 253-260. PMID: 3290050 | ||
| . | Levin, L.R., Kuret, J., Johnson, K.E., Powers, S., Cameron, S., Michaeli, M., Wigler, M. and Zoller, M. | 1988 | A mutation in the catalytic subunit of the cAMP-dependent protein kinase that disrupts regulation. Science, 240: 68-70. PMID: 2832943 | ||
| . | Cameron, S., Levin, L., Zoller, M. and Wigler, M. | 1988 | cAMP-Independent control of sporulation, glycogen metabolism and heat shock resistance in S. cerevisiae . Cell 53: 555-566. PMID: 2836063 | ||
| . | Toda, T., Cameron, S., Sass, P and Wigler, M. | 1988 | SCH9 , a gene of S. cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP dependent protein kinase catalytic Subunits . Genes and Development, 2: 517-527. PMID: 3290050 | ||
| . | Field, J., Nikawa, J., Broek, D., MacDonald, B., Rodgers, L., Wilson, I.A., Lerner, R.A. and Wigler, M. | 1988 | Purification of a RAS -responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Molecular and Cellular Biology, 8: 2159-2165. PMID: 2455217 | ||
| . | Young, D., O'Neill, K., Jessell, T. and Wigler, M. | 1988 | Characterization of the rat mas oncogene and its high level expression in the hippocampus and cerebral cortex of rat brain. Proc. Natl. Acad. Sci., 85: 5339-5342. PMID: 2455902 | ||
| . | Wigler, M., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J., and Ferguson, K. | 1988 | Studies of RAS function in the yeast S. Cerevisiae . Cold Spring Harbor Symposium, vol. LIII, pages 649-655. PMID: 3076094 | ||
| . | Powers, S., O'Neill, K. and Wigler, M. | 1989 | Dominant Yeast and Mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in S. cerevisiae . Molecular and Cellular Biology, 9 : 390-395. | ||
| . | Colicelli, J., Birchmeier, C., Michaeli, T., O'Neill, K., Riggs, M. and M. Wigler | 1989 | Isolation and characterization of a mammalian gene encoding a high affinity cAMP phosphodiesterase. Proc. Natl. Acad. Sci., 86: 3599-3603. | ||
| . | Sharma, S., Birchmeier, C., Nikawa, J., O'Neill, K., Rodgers, L. and Wigler, M. | 1989 | Characterization of the ros1 -gene products expressed in human glioblastoma cell lines. Oncogene Research, 5: 91-100. | ||
| . | Michaeli, T., Field, J., Ballester, R., O'Neill, K. and Wigler, M. | 1989 | Mutants of H- ras which interfere with RAS effector function in S. Cerevisiae. EMBO J., 8: 3039-3044. PMID: 2684634 | ||
| . | Ballester, R., Michaeli, T., Ferguson, K., Xu, H-P., McCormick, F. and Wigler, M. | 1989 | Genetic analysis of mammalian GAP expressed in yeast. Cell 59: 681-686. PMID: 2684416 | ||
| . | Young, D., Riggs, M., Field, J., Vojtek, A., Broek, D., and Wigler, M. | 1989 | The adenylyl cyclase gene from schizosaccharomyces pombe. Proc. Natl. Acad. Sci., 86: 7989-7993. | ||
| . | Field, J. Xu, H-P, Michaeli, T., Ballester, R., Sass, P., Wigler, M., Colicelli, J. | 1990 | Mutations of the adenylyl Cyclase gene that block RAS function in Saccharomyces Cerevisiae. Science, 247: 464-467. PMID: 2405488 | ||
| . | Field, J., Vojtek, A., Ballester, R., Bolger, G., Colicelli, J., Ferguson, K., Gerst, J., Kataoka, T., Michaeli, T., Powers, S., Riggs, M., Rodgers, L., Wieland, I., Wheland, B. and Wigler, M. | 1990 | Cloning and characterization of CAP , the Saccharomyces cerevisiae gene encoding the 70 kDa adenylyl cyclase associated protein. Cell, 61 : 319-327. | ||
| . | Weiland, I., Bolger, G., Asouline, G. and Wigler, M. | 1990 | A method for difference cloning: Gene amplification following subtractive hybridization. Proc. Natl. Acad. Sci., 87 : 2720-2724. PMID: 2138783 | ||
| . | Colicelli, J., Field, J., Ballester, R., Chester, N., Young, D., and Wigler, M. | 1990 | Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Mol. Cell. Biol., 10: 2539-2543. PMID: 2111437 | ||
| . | Birchmeier, C., O'Neill, K., Riggs, M., and Wigler, M. | 1990 | Characterization of ROS1 cDNA from a human glioblastoma cell line. Proc. Natl. Acad. Sci. USA 87: 4799-4803. PMID: 2352949 | ||
| . | Wigler, M. | 1990 | GAPs in understanding Ras. Nature, 346: 696-7. PMID: 2201920 | ||
| . | Xu, H.-P., Riggs, M., Rodgers, L., and Wigler, M. | 1990 | A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. Nucl. Acid Res. 18: 5304. PMID: 2205842 | ||
| . | Xu, H-P., Wang, Y., Riggs, M., Rodgers, L. and Wigler, M. | 1990 | Biological activity of the mammalian RAP genes in Yeast. Cell Regulation, 1: 763-769. PMID: 1983087 | ||
| . | Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M. and Collins, F. | 1990 | The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell, 63: 851-859. PMID: 2121371 | ||
| . | Gerst, J., Ferguson, K., Vojtek, A., Wigler, M. and Field, J. | 1991 | CAP: A bifunctional component of the S. cerevisiae adenylyl cyclase complex. Mol. Cell. Biol., 11: 1248-1257. PMID: 1996090 | ||
| . | Kawamukai, M., Ferguson, K., Wigler, M. and Young, D. | 1991 | Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regulation, 2: 155-164. PMID: 1863602 | ||
| . | Colicelli, J., Birchmeier, C., Rodgers, L., Riggs, M. and Wigler, M. | 1991 | Expression of three mammalian cDNAs which interfere with RAS function in S. cerevisiae. Proc. Natl. Acad. Sci. USA, 88: 2913-2917. PMID: 1849280 | ||
| . | Young, D., O'Neill, K., Broek, D. and Wigler, M. | 1991 | The adenylyl cyclase gene from Saccharomyces Kluyveri. Gene, 102: 129-132. PMID: 1864503 | ||
| . | Wang, Y., Xu, H.-P., Riggs, M., Rodgers, L. and Wigler, M. | 1991 | Byr2 , an S. pombe gene encoding a protein kinase capable of partial phenotypic suppression of ras1 - strains. Mol. Cell. Biol., 11: 3554-3563. PMID: 1883874 | ||
| . | Wang, Y., Boguski, M., Riggs, M., Rodgers, L. and Wigler, M. | 1991 | Sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation, 2: 453-465. PMID: 2046669 | ||
| . | Daar, I., Nebreda, A.R., Yew, N., Sass, P., Paules, R., Santos, E., Wigler, M. and Vande Woude, G.F. | 1991 | The ras oncoprotein and M-phase activity. Science, 253: 74-76. PMID: 1829549 | ||
| . | Vojtek, A., Haarer, B., Field, J., Gerst, J., Pollard, T.D., Brown, S. and Wigler, M. | 1991 | Evidence for a functional link between profilin and CAP in the yeast Saccharomyces cerevisiae . Cell, 66: 497-505. PMID: 1868547 | ||
| . | Xu, H.-P., Jung V., Riggs M., Rodgers L. and Wigler M. | 1992 | A gene encoding a protein with seven zinc finger domains which acts on the sexual differentiation pathways of Schizosaccharomyces pombe. Molecular Biology of the Cell, 3: 721-734. PMID: 1515675 | ||
| . | Gerst, J., Rodgers L., Riggs M. and Wigler M. | 1992 | SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: Genetic interactions with the RAS and CAP genes. Proc. Natl. Acad. Sci. USA, 89: 4338-4342. PMID: 1316605 | ||
| . | Kawamukai, M., Gerst, J., Field, J., Riggs, M., Rodgers, L., Wigler, M. and Young, D. | 1992 | Genetic and biochemical analysis of the adenylyl cyclase-associated protein, CAP, in Schizosaccharomyces pombe. Molecular Biology of the Cell, 3: 167-180. PMID: 1550959 | ||
| . | Shibuya, E.K., Polverino, A.J., Chang, E., Wigler, M. and Ruderman, J.V. | 1992 | Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc. Natl. Acad. Sci. USA, 89: 9831-9835. PMID: 1384061 | ||
| . | Andersen, L.B., Ballester, R., Marchuk, D.A. Chang, E., Gutmann, D.H., Saulino, A.M., Camonis, J., Wigler, M. and Collins, F.S. | 1993 | A conserved alternative splice in the von Recklinghausen neurofibromatosis ( NF1 ) gene produces two neurofibromin isoforms, both with GAP activity. Mol. Cell. Biol. 13: 487-495. PMID: 8437860 | ||
| . | Gutmann, D.H., Boguski, M., Marchuk, D., Wigler, M., Collins, F.S. and Ballester, R. | 1993 | Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. Oncogene, 8: 761-769. PMID: 8437860 | ||
| . | Michaeli, T., Bloom, T., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J., and Wigler, M. | 1993 | Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase deficient S. cerevisiae . J. Biological Chemistry, 268 : 12925-12932. PMID: 8438152 | ||
| . | Neiman, A.M., Stevenson, B.J., Xu, H-P., Sprague, G.F. Jr., Herskowitz, I., Wigler, M., and Marcus, S. | 1993 | Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol. Biol. of the Cell 4: 107-120. PMID: 8443406 | ||
| . | Lisitsyn, N., Lisitsyn, N. and Wigler, M. | 1993 | Cloning the differences between two complex genomes. Science 259: 946-951. PMID: 8438152 | ||
| . | Van Aelst, L., Barr, M., Marcus, S., Polverino, A. and Wigler, M. | 1993 | Complex formation between RAS and RAF and other protein kinases. Proc. Natl. Acad. Sci. USA, 90 : 6213-6217. PMID: 8327501 | ||
| . | Chardin, P., Camonis, J.H., Gale, N.W., Van Aelst, L., Schlessinger, J., Wigler, M. and Bar-Sagi, D. | 1993 | A human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science, 260: 1338-1343. PMID: 8493579 | ||
| . | Bolger, G., Michaeli, T., Martins, T., St. John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M. and Ferguson, K. | 1993 | A family of human phosphodiesterases homologous to the Dunce learning and memory gene of Drosophila melanogaster are potential targets for anti-depressant drugs. Molecular and Cellular Biology, 13: 6558-6571. PMID: 8413254 | ||
| . | Ohlmeyer, M.H.J., Swanson, M.N., Dillard, L.W., Reader, J.C., Asouline, G., Kobayashi, R., Wigler, M., Still, W.C. | 1993 | Complex synthetic chemical libraries indexed with molecular tags. Proc. Natl. Acad. Sci. USA, 90: 10922-10926. PMID: 7504286 | ||
| . | Lisitsyn, N.A., Segre, J.A., Kusumi, K., Lisitsyn, N.M., Nadeau, J.H., Frankel, W.N., Wigler, M. and Landers, E.S. | 1994 | Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nature Genetics, 6: 57-63. PMID: 8136836 | ||
| . | Xu, Hao-Peng, White, M., Marcus, S. and Wigler, M. | 1994 | Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe . Molecular and Cellular Biology, 14: 50-58. PMID: 8264618 | ||
| . | Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M. and Broek, D. | 1994 | Two types of ras mutants that dominantly interfere with activators of RAS. Mol. Cell. Biol. 14: 3707-3718. PMID: 8196614 | ||
| . | Marcus, S., Barr, M., Polverino, A., and Wigler, M. | 1994 | Complexes between STE5 and components of the yeast pheromone-responsive MAP kinase module. Proc. Natl. Acad. Sci. USA, 91: 7762-7766. PMID: 8052657 | ||
| . | Chang, E., Barr, M., Wang, Y., Jung, V., Xu, H.-P., and Wigler, M. | 1994 | Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell, 79: 131-141. PMID: 7923372 | ||
| . | Lisitsyn, N.A., Lisitsina, N.M., Dalbagni, G., Barker, P., Sanches, C.A. Gnarra, J., Linehan, W.M. Reid, B.J. and Wigler, M. | 1995 | Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc. Natl. Acad. Sci. USA, 92: 151-155. PMID: 7816807 | ||
| . | White, M., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. and Wigler, M. | 1995 | Multiple RAS functions can contribute to mammalian cell transformation. Cell, 80: 533-541. PMID: 7867061 | ||
| . | Jung, V., Chen, Li, Hofmann, S.L., Wigler, M., Powers, S. | 1995 | Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block attachment and palmitoylation of Ras proteins. Mol. Cel. Biol. 15: 1333-1342. PMID: 7532279 | ||
| . | Van Aelst, L., White, M. and Wigler, M. | 1994 | Ras partners. Cold Spring Harbor Symposium on Quantative Biology, Volume 59: pp. 181-186. | ||
| . | Lisitsyn, N.A., Leach, F.S., Vogelstein, B. and Wigler, M. | 1995 | Detection of genetic loss in tumors by representational difference analysis. Cold Spring Harbor Symposium on Quantative Biology, Volume 59: pp. 585-587. PMID: 7587116 | ||
| . | Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M.H., Wigler, M. | 1995 | Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast, Schizosaccharomyces pombe . Proc. Natl. Acad. Sci. USA, 92: 6180-6184. PMID: 7597098 | ||
| . | Joneson, T., White, M.A., Wigler, M.H. and Bar-Sagi, D. | 1996 | Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271: 810-812. PMID: 8628998 | ||
| . | Thiagalingam, S., Lisitsyn, N.A., Hamaguchi, M., Wigler, M.H., Willson, J.K.V., Markowitz, S.D., Leach, F.S., Kinzler, K.W., Vogelstein, B. | 1996 | Evaluation of the FHIT gene in colorectal Cancers. Cancer Research, 56: 2936-2939. PMID: 8674044 | ||
| . | Khosravi-Far, R., White, M.A., Westwick, J.K., Solski, P.A., Chrzanowska-Wodnicka, M., Van Aelst, L., Wigler, M., Der, C.J. | 1996 | Oncogenic Ras activation of Raf/mitogen-activation protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol. Cell. Biol. 16: 3923-3933. PMID: 8668210 | ||
| . | Barr, M.M., Tu, H., Van Aelst, L., Wigler, M. | 1996 | Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Mol. Cell. Biol. 16: 5597-5603. PMID: 8816472 | ||
| . | White, M.A., Vale, T., Camonis, J.H., Schaefer, E., Wigler, M.H. | 1996 | A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J. Biol. Chem., 271: 16439-16442. | ||
| . | Xu, H.-P., Yanak, B.L., Wigler, M.H., and Gorin, M.B. | 1996 | New polymorphic markers in the vicinity of the pearl locus on mouse Chromosome 13. Mammalian Genome, 7: 16-19. | ||
| . | Li, J., Yen, C., Liaw, D., Podsypanina,K., Bose, S., Wang, S., Puc, J., Miliarcsis, C., Rodgers, L., McCombie, R., Bigner, S.H., Giovanella, C., Ittman, M., Tycko, B., Hibshoosh, H., Wigler, M.H. and Parsons, R. | 1997 | PTEN a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275: 1943-1947. PMID: 9072974 | ||
| . | Myers, M.P., Stolarov, J.P., Eng, C., Li, J., Wang, S.I., Wigler, M., Parsons, R. and Tonks, N.K. | 1997 | P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci., USA 94: 9052-9057. PMCID: PMC23024 | ||
| . | Tu, H., Barr, M., Dong, D.L. and Wigler, M. | 1997 | Multiple regulatory domains on the Byr2 protein kinase. Mol. Cell. Biol., 17: 5876-5887. PMID: 9315645 | ||
| . | Hamaguchi, M., O'Connor, E.A., Chen, T., Parnell, L., McCombie, R.W., and Wigler, M. | 1998 | Rapid isolation of cDNA by hybridization. Proc.Natl.Acad.Sci. 95: 3764-3769. PMCID: PMC19911 | ||
| . | Lucito, R., Nakamura, M., West, J.A., Han, Y., Chin, K., Jensen, K., McCombie, R., Gray, J.W., and Wigler, M. | 1998 | Genetic analysis using genomic representations. Proc.Natl.Acad.Sci.USA 95: 4487-4492. PMCID:22516 | ||
| . | Webb, C.P., Van Aelst, L., Wigler, M.H. and Vande Woude, G.F. | 1998 | Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc. Natl. Acad. Sci. USA 95: 8773-8778. PMCID: PMC21152 | ||
| . | Myers, M., Pass, I., Batty, I.H., Van der Kaay, J., Stolarov, J.P., Hemmings, B.A., Wigler, M.H., Downes, C.P., Tonks, N.K. | 1998 | The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl. Acad. Sci. USA, 95: 13513-13518. PMCID: PMC24850 | ||
| . | Tu, H. and Wigler, M. | 1999 | Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol. Cell. Biol., 19: 602-611. PMID: 9858584 | ||
| . | Dong, D.L., Liu, R., Sherlock, R., Wigler, M., Nestler, P.H. | 1999 | Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxy-terminus. Chem. & Biol., 6: 133-141. PMID: 10074468 | ||
| . | Lucito, R., West, J., Reiner, A., Alexander, J., Esposito, D., Mishra, B., Powers, S., Norton, L., and Wigler, M. | 2000 | Detecting gene copy number fluctuations in tumor cells by microarray analyis of genomic representations. Genome Research, 10: 1726-1736. PMCID: PMC310939 | ||
| . | Wen, S., Stolarov, J., Myers, M.P., Su, J.D., Wigler, M.H., Tonks, N.K., and Durden, D.L. | 2001 | PTEN controls tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA, 98: 4622-4627. PMCID: PMC31884 | ||
| . | Casey, W., Mishra, B. and Wigler, M. | 2001 | Placing probes along the genome using pairwise distance data. Algorithms in Bioinformatics, O. Gasscuel and B.M.E. Moret (eds.): First International Workshops, Arhus, Denmark. Springer-Verlag Berlin Heidelberg WABI 2001, LNCS, 2149: 52-68. | ||
| . | Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G.J., Wigler, M. and Mittal, V. | 2001 | Design of a retroviral-mediated ecdysone inducible system an its application to the expression profiling of the PTEN tumor suppressor. Proc. Natl. Acad. Sci., 98: 13043-13048. PMCID: 60821 | ||
| . | Scheffzek, K., Grünewald, P., Wohlgemuth, S., Kabsch, W., Tu, H., Wigler, M., Wittinghofer, A., Herrmann, C. | 2001 | The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure, 9: 1043-1050. PMID: 11709168 | ||
| . | Wigler, M. and Mishra, B. | 2002 | Wild by Nature. Science, 296: 1408-1408. PMID: 12029116 | ||
| . | Hamaguchi, M., Meth, J.L., von Klitzing, C. Wei, W., Esposito, D., Rodgers, L. Walsh, T., Welch, P., King, M-C. and Wigler, M.H. | 2002 | DBC2, a candidate for a tumor suppressor gene involved in breast cancer Proc. Natl. Acad. Sci., USA 99: 13647-13652. PMCID: PMC129730 | ||
| . | Mu, D., Chen, L., Zhang, X., See, L-H., Koch, C.M., Yen, C., Tong, J.J., Spiegel, L., Nguyen, K.C.Q., Servoss, A., Peng, Y., Pei, L., Marks, J.R., Lowe, S., Hoey, T., Jan, L.Y., McCombie, W.R., Wigler, M.H., Powers, S. | 2003 | Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3: 297-302. PMID: 12676587 | ||
| . | Lucito, R., Healy, J., Alexander, J., Reiner, A., Esposito, D., Chi, M., Rodgers, L., Brady, A., Sebat, J., Troge, J., West, J., Rostan, S., Nguyen, K.C.Q., Powers, S., Ye, K.Q., Olshen, A., Venkatraman, E., Norton, L. and Wigler, M. | 2003 | Representational oligonucleotide microarray analysis: a high –resolution method to detect genome copy number variation. Genome Research 13: 2291-2305. PMCID: PMC403708 | ||
| . | Healy, J., Thomas, E., Schwartz, J.T. and Wigler, M. | 2003 | Annotating large genomes with exact word matches. Genome Research 13: 2306-2315. PMCID: PMC403711 | ||
| . | Thomas, E.E., Srebro, N., Sebat, J., Navin, N., Healy, J., Mishra, B., and Wigler, M. | 2004 | Distribution of short, paired duplications in mammalian genomes. Proc. Natl. Acad. Sci., USA, 101: 10349-10354. PMCID: PMC478600 | ||
| . | Sebat, J., Muthuswamy, L., Troge, J., Alexander, J., Young, J., Lundin, P., Maner, S., Massa, H., Walker, M., Chi, M., Navin, N., Lucito, R., Healy, J., Hicks, J., Ye, K., Reiner, A., Gilliam, T.C., Trask, B., Patterson, N., Zetterberg, A., Wigler, M. | 2004 | Large-Scale Copy Number Polymorphism in the Human Genome. Science, 305: 525-528. PMID: 15273396 | ||
| . | Olshen, A., Venkatraman, E.S., Lucito, R., and Wigler, M. | 2004 | Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics, 5: 557-572. PMID: 15475419 | ||
| . | Daruwala, R.-S, Rudra, A., Ostrer, H., Lucito, R., Wigler, M. and Mishra, B. | 2004 | A versatile statistical analysis algorithm to detect genome copy number variation. Proc. Natl. Acad. Sci., 101: 16292-16297. PMCID: 528962 | ||
| . | Jobanputra, V., Sebat, J., Chung, W., Anyane-Yeboa, K., Wigler, M. and Warburton, D. | 2004 | Application of ROMA (Representational Oligonucleotide Microarray Analysis) to patients with known cytogenetic rearrangements. Genetics in Medicine, 7: 111-118. PMID 15714078 | ||
| . | West, J., Healy, J., Casey, W., Mishra, B., and Wigler, M. | 2006 | Validation of S. Pombe Sequence Assembly by Micro-Array Hybridization. Journal of Computational Biology 13: 1-20. PMID: 16740623 | ||
| . | Lakshmi, B., Hall, I.M., Egan, C., Alexander, J., Leotta, A., Healy, J., Zender, L., Spector, M., Xue, W., Lowe, S.W., Wigler, M. and Lucito, R. | 2006 | Mouse genomic Representational Oligonucleotide Microarray Analysis: detection of copy number variations in normal and tumor. Proc. Natl. Acad. Sci. USA 103: 11234-11239. PMCID: 1544071 | ||
| . | Navin, N., Grubor, V., Hicks, J., Leibu, E., Thomas, E., Troge, J., Riggs, M., Lundin, P., Maner, lS., Sebat, J., Zetterberg, A. and Wigler, M. | 2006 | Prober: Oligonucleotide FISH probe design software. Bioinformatics, 22: 2437-2438. | ||
| . | Zender, L., Spector, M.S., Xue, W., Flemming, P., Cardon-Cardo, C., Silke, J., Fan, S-T., Luk, J.M., Wigler, M., Hannon, G.J., Mu, D., Lucito, R., Powers, S., and Lowe, S. | 2006 | Identification and validation of onogenes in liver cancer using an integrative approach. Cell 125: 1253-1267. PMCID: 16814713 | ||
| . | Hicks, J., Krasnitz,A., Lakshmi, B., Navin, N., Riggs, M., Leibu, E., Esposito, D., Alexander, J., Troge, J., Grubor,V., Yoon, S., Wigler, M., Ye, K., Børresen-Dale, A-L., Naume, B., Schlicting, E., Norton, L., Hagerstrom, T., Skoog, L., Auer G., Maner, S., Lundin, P., and Zetterberg, A. | 2006 | Novel Patterns of genomic rearrangement and their association with survival in breast cancer. Genome Research 16:1465–1479. PMCID: 1665631 | ||
| . | Pelham, R.J., Rodgers, L., Hall, I., Lucito, R., Nquyen, K.C.Q., Navin, N., Hicks, J., Mu, D., Powers, S., Wigler, M. and Botstein, M. | 2006 | Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc. Natl. Acad. Sci. USA 103: 19848-19853. PMCID: 1698871 | ||
| . | Sebat, J., Lakshmi, B., Malhotra, D., Lese-Martin, C., Troge, J., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., Leotta, A., Pai, D., Zhang, R., Lee, Y-H., Hicks, J., Spence, S.J., Lee, A.T., Puura, K., Lehtimäki, T., Ledbetter, D., Gregersen, P.K., Bregman, J., Sutcliffe, J.S., Jobanputra, V., Chung, W., Warburton, D., King, M-C., Skuse, D., Geschwind, D.H., Gilliam, T.C., Ye, K., Wigler, M. | 2007 | Strong association of de novo copy number mutations with autism. Science 316: 445-449. PMCID: 17363630 | ||
| . | Zhao, X., Leotta, A., Qiu, S., Kustanovich, V., Lajonchere, C., Geschwin, D.H., Lord, C., Sebat, J., Ye., K. and Wigler, M. | 2007 | A unified genetic theory for sporadic and inherited autism. Proc. Natl. Acad. Sci., USA 104: 12831-12836. PMCID: 1933261 | ||
| . | Egan, C.M., Sridhar, S., Wigler, M., Hall, I.M. | 2007 | Recurrent DNA copy number variation in the laboratory mouse. Nat. Genet., 39: 1384-1389. PMID: 17965714 | ||
| . | Lucito, R., Suresh, S., Walter, K., Pandey, A., B. Lakshmi, Krasnitz, A., Sebat, J., Wigler, M., Klein, A.P., Brune, K., Palmisano, E., Maitra, A., Goggins, M., and Hruban, R.H. | 2007 | Copy-Number Variants in Patients with a Strong Family History of Pancreatic Cancer. Cancer Biol Ther. 6(10) 1592-9. PMCID: 17912030 | ||
| . | Alarcon, M., Abrahams, B.S., Stone, J.L., Duvall, J.A., Perederiy, J.V., Bomar,J.M., Sebat, J., Wigler, M., Martin, C.L., Ledbetter, D.H., Nelson, S.F., Cantor, R.M., Geschwind, D.H. | 2008 | Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J. Hum. Genet., 82: 150-159. PMCID: 2253955 | ||
| . | Xue, W., Krasnitz, A., Lucito, R., Sordella, R., VanAelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M., Powers, S., Zender, L., Lowe, S.W. | 2008 | DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev 22: 1439-1444. PMCID: 2418580 | ||
| . | Grubor, V., Krasnitz, A., Troge, J.E., Meth,J.L., Lakshmi, B., Kendall, J.T., Yamrom, B., Alex, G., Pai, D., Navin, N., Hufnagel, L.A., Lee, Y-H., Cook, K., Allen, S., Rai, K.R., Damle, R.N., Calissano, C., Chiorazzi, N., Wigler, M. and Esposito, D. | 2008 | Novel genomic alterations and clonal evolution in Chronic Lymphosytic Leukemia revealed by Representational Oligonucleotide Microarray Analysis (ROMA). Blood, 113: 1294-1303. PMCID: 18922857 | ||
| . | Zender, L., Xue, W., Zuber, J., Semighini, C.P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J.M., Schirmacher, P., McCombie, R.W., Wigler, M., Hicks, J., Hannon, G.J., Powers, S., Lowe, S.W. | 2008 | An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell 135: 852-864. PMCID: 19012953 | ||
| . | Hodges, E., Smith, A.D., Kendall, J., Xuan, Z., Ravi, K., Rooks, M., Zhang, M.Q., Ye, K., Bhattacharjee, A., Brizuela, L., McCombie, R., Wigler, M., Hannon, G.J. and Hicks, J. | 2009 | High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Research, 19: 1593-1605. PMCID: 2752124 | ||
| . | Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. | 2009 | Functional Identification of tumor-suppressor genes through an in vivo RNA interference screen in a muse lymphoma mode. Cancer Cell. 16:324-35. PMCID: 2829755 | ||
| . | Navin, N., Krasnitz, A., Rodgers, R., Cook, K., Meth, J., Kendall, J., Riggs, M., Eberling, Y., Troge, J., Grubor, V., Levy, D., Lundin, P., Månér, S., Zetterberg, A., Hicks, J. and Wigler, M. | 2010 | Inferring tumor progression from genomic heterogeneity. Genome Research, 20: 68-80. PMCID: 2798832. | ||
| . | Russnes, H.G., Moen Vollan, H.K., Lingjærde, O.C., Krasnitz, A., Lundin, P., Naume, B., Sørlie, T., Borgen, E., Rye., I.H., Langerød, A., Chin, S-F., Teschendorff, A.E., Stephens, P.J., Susanne Månér, S., Schlichting, E., Baumbusch, L.O., Kåresen, R., Stratton, M.P., Wigler, M., Caldas, C., Zetterberg, A., James Hicks, J., Børresen-Dale, A.-L. | 2010 | Genomic architecture characterizes tumor progression paths and fate in breast cancer patients. Science: Translational Medicine, 2: 38ra47. PMCID: 20592421 | ||
| . | Kamalakaran, S., Vinay Varadan, V., Giercksky Russnes, H.E., Levy, D., Kendall, J., Janevski, A., Riggs, M., Banerjee, N., Synnestvedt, M., Schlichting, E., Kåresen, R., Karensen, R., Shama Prasada, K., Rotti, H., Rao, R., Rao, L., Eric Tang, M.H., Satyamoorthy, K., Lucito, R., Wigler, M., Dimitrova, N., Naume, B., Borresen-Dale, A.-L., Hicks, J.B. | 2011 | DNA methylation patterns in luminal breast cancer differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Molecular Oncology, 5: 77-92. PMCID: 21169070 | ||
| . | Navin, N., Kendall, J., Troge, J., Andrews, P., Rodgers, L., McIndoo, J., Cook, K., Stepansky, A., Levy, D., Esposito, D., Muthuswamy, L., Krasnitz, A., McCombie, R., Hicks, J., Wigler, M. | 2011 | Tumor evolution inferred by single cell sequencing. Nature, 472: 90-94. PMCID: 21399628 | ||
| . | Horev, G., Ellegood, J., Lerch, J.P., Son, Y.E., Muthuswamy, L., Vogel, H., Krieger, A.M., Buja, A., Henkelman, R.M., Wigler, M., Mills, A.A. | 2011 | Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc. Natl. Acad. Sci., USA, 108: 17076-17081. PMCID: 3193230 | ||
| . | Levy, D., Ronemus, M., Yamrom, B., Lee, Y-H., Leotta, A., Kendall, J., Marks, S., Lakshmi, B., Pai, D., Ye, K., Buja, A., Krieger, A., Yoon, S., Troge, J., Rodgers, L., Iossifov, I., Wigler, M. | 2011 | Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron, 70: 886-897. PMCID: 21658582 | ||
| . | Gilman, S.R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., and Vitkup, D. | 2011 | Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron 70, 898-907. PMCID: 3607702 | ||
| . | Lee, Y-H., Ronemus, M., Kendall, J., Lakshmi, B., Leotta, A., Levy, D., Esposito, D., Grubor, V., Ye, K., Wigler, M., and Yamrom, B. | 2012 | Reducing system noise in copy number data using principal components of self-self hybridizations. Proc. Natl. Acad. Sci., USA, 109: E103-E110. PMCID: 3271883 | ||
| . | Baslan, T., Kendall, K., Rodgers, L., Cox, H., Riggs, R., Stepansky, A., Troge, J., Kandasamy, R., Esposito, D., B. Lakshmi, Wigler, M., Navin, N., and Hicks, J. | 2012 | Genome wide copy number analysis of single cells. Nature Protocols, 7: 1024-1041. PMCID: 5069701 | ||
| . | Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y-H., Narzisi, G., Leotta, A., Kendall, J., Grabowska, E., Ma, B., Marks, S., Rodgers, L., Stepansky, A., Troge, J., Andrews, Bekritsky, M., Pradhan, K., Ghiban, E., Kramer, M., Parla, J., Demeter, R., Fulton, L., Fulton, R.S., Magrini, V.J., Ye, K., Darnell, J.C., Darnell, R.B., Mardis, E.R., Wilson, R.K., Schatz, M.C., McCombie, W.R., Wigler, M. | 2012 | De novo gene disruptions in children on the autistic spectrum. Neuron, 74: 285-299. PMCID: 3619976 | ||
| . | Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, A.R., Simon, J., Zhang, J., Luo, W., Hicks, J., Zender, L., Wang, X-W., Powers, S., Wigler, M., Lowe, S.W. | 2012 | A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc. Natl. Acad. Sci., USA, 109: 8212-8217. PMCID: 3361457 | ||
| . | Stadler, Z.K., Esposito, D., Shan, S., Vijai, J., Yamrom, B., Levy, D., Lee, Y-H., Kendallo, J., Leotta, A., Ronemus, M., Hansen, N., Sarrel, K.,Rauy-Murthy, R., Schrader, K., Kauff, N., Klein, R.J., Lipkin, S.M., Murali, R., Robson, M., Sheinfeld, J., Feldman, D., Bosl, G., Norton, L., Wigler, M., and Offit, K. | 2012 | Rare De Novo germline copy-number variation in testicular cancer. The American Journal of Human Genetics, 91: 379-383. PMCID: 3415553 | ||
| . | Wigler, M. | 2012 | Broad applications of single-cell nucleic acid analysis in biomedical research. Genome Medicine 2012, 4:79. PMCID: 3580448 | ||
| . | Krasnitz, A., Sun, G., Andrews, P., Wigler, M. | 2013 | Target inference from collections of genomic intervals. Proc. Natl. Acad. Sci., USA, 110: E2271-E2778. PMCID: 3690846 | ||
| . | Donnenberg, A.D., Hicks, J.B., Wigler, M., and Donnenberg, V.S. | 2013 | The cancer stem cell: Cell type or cell state? Cytometry, A 83, 5-7. PMCID: 4154500 | ||
| . | Shi, J. Whyte, W.A., Zepeda-Mendoza, C.J., Milazzo, J.P., Shen, C., Roe, J-S., Minder, J.L., Mercan, F., Wang, E., Eckersley-Maslin, M.A., Campbell, A.E., Kawaoka, S., Shareef. S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R.G., Wigler, M.H., Blobel, G.A., Zuber, J., Spector, D.L., Young, R.A., Vakoc, C.R. | 2014 | Role of SWI/SNF in acute leukemia maintenance and enhanced-mediated Myc regulation. Genes & Development 27: 2648-2662. PMCID: 3877755 | ||
| . | Ronemus, M., Iossifov, I., Levy, D. Wigler, M. | 2014 | The role of de novo mutation in the genetics of autism spectrum disorders. Nature Reviews Genetics, 15: 133-141. | ||
| . | Warburton, D., Ronemus, M., Kline, J., Jobanputra, V., Williams, I., Anyane-Yeboa, K., Chung, W., Yu, L., Wong, N., Awad, D., Yu, C-y., Leotta, A., Kendall, J., Yamrom, B., Lee, Y-h., Wigler, M., Levy, D. | 2014 | The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease. Hum. Genet., 133: 11-27. PMCID: 3880624 | ||
| . | Dago, A.E., Stepansky, A., Carlsson, A., Luttgen, M., Kendall, J., Baslan, T., Kolatkar, A., Wigler, M., Bethel, K., Gross, M.E., Hicks, J., Kuhn, P. | 2014 | Rapid Phenotypic and Genomic Change in Response to Therapeutic Pressure in Prostate Cancer Inferred by High Content Analysis of Single Circulating Tumor Cells. PLOS One, 9: e101777. PMCID: 4118839 | ||
| . | Narzisi, G., O'Rawe, J.A., Iossifov, I., Fang, H., Lee, Y-pH., Wang, Z., Weu, Y., Lyon, G.J., Wigler, M., Schatz, M.C. | 2014 | Accurate de novo and Transmitted Indel Detection in Exome-Capture Data Using Microassembly. Nature Methods, 11: 1033-1036. PMCID: 4180789. | ||
| . | Levy, D. and Wigler, M. | 2014 | Facilitated Sequence Counting and Assembly by Template Mutagenesis. Proc. Natl. Acad. Sci., USA, 111: E4632-4637. PMCID: 4217440 | ||
| . | Iossifov, I., O'Roak, B.J., Sanders, S., Ronemus, M., Krumm, N., Levy, D., Stessman, H., Withersoon, K., Vives, L., Patterson, K., Smith, J., Paeper, B., Nickerson, D.A., Dea, J., Dong, S., Gonzalez, L.E., Mandell, J.D., Mane, S.M., Murtha, M.T., Sullivan, C.A., Walker, M.F., Waqar, Z., Wei, L., Willsey, A.J., Yamrom, B., Lee, Y-h., Grabowska, E., Dalgic, E., Wang, Z., Marks, S., Anders, P., Leotta, A., Kendall, J., Hakker, I., Rosenbaum, J., Ma, B., Rodgers, L., Troge, J., Narzisi, G., Yoon, S., Schatz, M.C., Ye, K., McCombie, W.R., Shendure, J., Eichler, E.E., State, M.W. and Wigler, M. | 2014 | The contribution of de novo coding mutations to austism spectrum disorder. Nature, 515: 216-221. PMCID: 4313871 | ||
| . | Rye, I.H., Ludin, P., Maner, S., Fjellda, R., Naume, B., Wigler, M., Hicks, J., Borresen-Dale, A., Zetterberg, A., Russnes, H.G. | 2014 | Quantitative mutigene FISH on breast carcinomas identified der (1;16) (q10;p10) as an early event in luminal A tumors. Genes Chromosomes Cancer, 54: 235-248. PMCID: 4369137 | ||
| . | Jayaprakash, A.D., Benson, E.K., Gone, S., Liang, R., Shim, J., Lamvertini, L., Toloue, M.M., Wigler, M., Aaronson, S.A., Sachidanandam, R. | 2015 | Stable Heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic Acids Research, 43: 2177-2178. PMCID: 4344500 | ||
| . | Baslan, T., Kendall, J., Ward, B., Cox, H., Leotta, A., Rodgers, L., Riggs, M., D’Italia, S., Sun, G., Yong, M., Miskimen, K., Gilmore, H., Dimitrova, N., Krasnitz, A., Harris, L., Wigler, M., Hicks, J. | 2015 | Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Research, 25: 714-724. PMCID: 4417119 | ||
| . | Garvin, T., Aboukhalil, R., Kendall, J., Baslan, T., Atwal, G.S., Hicks, J., Wigler, M., Schatz, M.C. | 2015 | Interactive analysis and quality assessment of single-cell copy-number variations. Nature Methods, 12: 1058-1060. PMCID: 4775251 | ||
| . | Mukhopadhyay, S., Wigler, M., Levy, D. | 2015 | Simple genetic models for autism spectrum disorder. BioRxiv/2015/017301. | ||
| . | Iossifov, I., Levy, D., Allen, J., Ye, K., Ronemus, M., Lee, Y-H., Yamrom, B., Wigler, M. | 2015 | Low load for disruptive mutations in autism genes and their biased transmission. Proc. Natl. Acad. Sci. USA., 112: E5600-7. PMCID 4611648 | ||
| . | Baslan, T., Kendall, J., Rodgers, L., Cox, H., Riggs, M., Stepansky, A., Troge, J., Ravi, K., Esposito, D., Lakshmi, B., Wigler, M., Navin, N., Hicks J. | 2016 | Corrigendum: Genome-wide copy number analysis of single cells. Nature Protocols, 11: 616. PMID: 26914320 | ||
| . | Wang, Z., Andrews, P., Kendall, J., Ma, B., Hakker, I., Rodgers, L., Ronemus, M., Wigler, M. and Levy, D. | 2016 | SMASH, a fragmentation and sequencing method for genomic copy number analysis. Genome Research, 26: 1-8. PMCID: 4889966 | ||
| . | Andrews, P.A., Iossifov, I., Kendall, J., Marks, S., Muthuswamy, L., Wang, Z., Levy, D. and Wigler, M. | 2016 | MUMdex: MUM-based structural variation detection. bioRxiv/2016/078261. | ||
| . | Fang, H., Bergmann, E., Arora, K., Vacic, V., Zody, M., Iossifov, I., O'Rawe, J., Wu, Y., Jimenez Barron, L., Rosenbaum, J., Ronemus, M., Lee, Y-H., Wang, z., Dikoglu, E., Jobanputra, V., Lyon, G., Wigler, M., Schatz, M., and Narzisi, G. | 2016 | Indel variant analysis of short-read sequencing data with Scalpel. Nature Protocol, 11: 2529-2548. PMCID: 5507611 | ||
| . | Ye, K., Iossifov, I., Levy, D., Buja, A., Krieger, A., and Wigler M. | 2017 | Measuring shared variants in cohorts of discordant siblings with applications to autism. Proc. Natl. Acad. Sci. USA, 114: 7073-7076. PMCID: 5502605 | ||
| . | Krasnitz, A., Kendall, J., Alexander, J., Levy, D., and Wigler, M. | 2017 | Early detection of cancer in blood using single-cell analysis: A proposal. Trends in Molecular Medicine, 23: 594-603. PMCID: 5502711 | ||
| . | Alexander, J., Kendall, J., McIndoo, J., Rodgers, L., Aboukhalil, R., Levy, D., Stepansky, A., Sun, G., Riggs, M., Cox, H., Hakker, I., Nowak, D., Laze, J., Lukani, E., Srivastava, A., Gruschow, S., Yadav, S., Robinson, B., Atwal, G., Trotman, L., Lepor, H., Hicks, J., Wigler, M. and Krasnitz, A. | 2017 | Utility of single cell genomic evaluation of prostate cancer. Cancer Research, 78: 348-358. PMCID: 5771881 | ||
| . | Buja, A., Volfovsky, N., Krieger, A., Lord, C., Lash, A.E., Wigler, M., and Iossifov, I. | 2017 | Damaging de novo mutations diminish motor skills in children on the autism spectrum. PNAS, 15: E1859-E1866. PMCID: 5828599 | ||
| . | Buja, A., Volfovsky, N., Krieger, A., Lord, C., Lash, A.E., Wigler, M., and Iossifov, I. | 2017 | Damaging mutations are associated with diminished motor skills and IQ in children on the autism spectrum. bioRxiv/2017/141200. | ||
| . | Munoz, A., Yamrom, B., Lee, Y-h., Marks, S., Lin, K-T., Wang, Z., Krainer, A.R., Darnell, R.B., Wigler, M. and Iossifov, I. | 2017 | De novo indels within introns comtribute to ASD incidence. bioRxiv/2017/137471. | ||
| . | Kumar, V., Rosembaum, J., Wang, Z., Forcier, T., Ronemus, M., Wigler, M. and Levy, D. | 2018 | Partial bisulfite conversion for unique template sequencing. Nucleic Acids Research, 46: e10. PMCID: 5778454 | ||
| . | Li, S., Kendall, J., Park, S., Wang, Z., Alexander, J., Moffitt, A., Ranade, N., Danyko, C., Gegenhuber, B., Fischer, S., Robinson, B.D., Lepor, H., Tollkuhn, J., Gillis, J., Brouzes, E., Krasnitz, A., Levy, D. and Wigler, M. | 2019 | Copolymerization of single-cell nucleic acids into balls of acrylamide gel. Genome Research, 30: 49-61. PMCID: 6961581 | ||
| . | Moffitt, A.B., Spector., M.S., Andrews, P., Kendall, J., Alexander, J., Stepansky, A., Ma, B.C., Kolitz, J., Chiorazzi, N., Allen, S.L., Krasnitz, A., Wigler, M., Levy, D. and Wang, Z. | 2020 | Multiplex accurate sensitive quantitation (MASQ) with application to minimal residual disease in acute myeloid leukemia. Nucleic Acids Research, 48: e40. PMCID: 7144909 | ||
| . | Chorbadjiev, L., Kendall, J., Alexander, J., Zhygulin, V., Song, J., Wigler, M. and Krasnitz, A. | 2020 | An integrated computational pipeline for single-cell genomic profiling. JCO Clin. Cancer Inform., 4: 464-471. | ||
| . | Baslan, T., Kendall, J., Volyanskyy, K., McNamara, K., Cox, H., D’Italia, S., Ambrosio, F., Riggs, M., Rodgers, L., Leotta, A., Song, J., Mao, Y., Wu, J., Shah, R., Merida, R.G., Chadalavada, K., Nanjangud, G., Varadan, V., Gordon, A., Curtis, C., Krasnitz, A., Dimitrova, N., Harris, L., Wigler, M., and Hicks, J. | 2020 | Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing. eLife Science, 9: 51480. | ||
| . | Vasudevan, A., Baruah, P.S., Smith, J.C., Wang, Z., Sayles, N.M., Andrews, P., Kendall, J., Leu, J., Chunduri, N.K., Levy, D., Wigler, M., Storchová, Z., Sheltzer, J.M. | 2020 | Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Dev Cell. 4: 413-428.e6. | ||
| . | Miyabayashi, K, Baker, LA, Deschênes, A,Traub, B, Caligiuri, G, Plenker, D, Alagesan, B, Belleau, P, Li, S, Kendall, J, Jang, GH, Kawaguchi, RK, Somerville, TDD, Tiriac, H, Hwang, CI, Burkhart, RA, Roberts, NJ, Wood, LD, Hruban, RH, Gillis, J, Krasnitz, A, Vakoc, CR, Wigler, M. Notta, F, Gallinger, S, Park, Y, Tuveson, DA. | 2020 | Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes. Cancer Discovery, 10: 1566-1589. PMCID: PMC7664990 | ||
| . | Yoon S, Munoz A, Yamrom B, Lee Y-h, Andrews P, Marks S, Wang Z, Reeves C, Winterkorn L, Krieger AM, Buja, A, Pradhan K. Ronemus M, Baldwin KK, Levy D, Wigler M, Iossifov I. | 2021 | Rates of contributory de novo mutation in high and low risk autism families. Nature Communications Biology, 4: 1026. PMCID: PMC8410909 | ||
| . | Li S, Park S, Ye C, Danyko C, Wroten M, Andrews P, Wigler M, and Levy D. | 2022 | Targeted de novo phasing and long-range assembly by template mutagenesis. Nucleic Acids Research, 50: e103. PMCID: PMC9561374 | ||
| . | Wang Z, Moffitt A, Andrews P, Wigler M, Levy D. | 2022 | Accurate measurement of microsatellite length by disrupting its tandem repeat structure. Nucleic Acids Research 50: e116. PMC9723644 | ||
| . | Wroten M, Yoon S, Andrews P, Yamrom B, Ronemus M, Buja A, Krieger AM, Levy D, Ye K, Wigler M, and Iossifov I. | 2023 | Sharing parental genomes by siblings concordant or discordant for autism. Cell Genomics 3: 100319. PMCID: PMC10300587 | ||
| . | Li S, Alexander J, Kendall J, Andrews P, Rose E, Orjuela H, Park S, Podszus C, Shanley L, Ma R, Rishi A, Donoho DL, Goldberg GL, Levy D, and Wigler M. | 2023 | High-throughput single-nucleus hybrid sequencing reveals genome-transcriptome correlations in cancer. In progress. | ||
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publications.txt · Last modified: 2023/10/13 10:48 by patty