Research Publications

# Authors Year Title PDF Notes
. Wigler, M.H. and Weinstein, I.B. 1975 A preparative method for obtaining enucleated mammalian cells. Biochemical and Biophysical Research Commun. 63 : 669-674. PMID: 1169063 PDF
. Wigler, M.H., Ford, J.P. and Weinstein, I.B. 1975 Glucocorticoid inhibition of fibrinolytic activity production by tumor cells. Cold Spring Harbor Symp. on Proteases and Biological Control, 849-856. PDF
. Wigler, M.H. and Weinstein, I.B. 1976 A tumor promoter induces plasminogen activator. Nature 259: 232-233. PMID: 1250353 PDF
. Wigler, M.H. and Axel, R. 1976 Nucleosomes in metaphase chromosomes. Nucleic Acids Res. 3: 1463-1472. PMID: 958895 PDF
. Wigler, M.H., Silverstein, S., Lee, L.S., Pellicer, A., Cheng, Y. and Axel, R. 1977 Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell 11: 223-232. PMID: 194704 PDF
. Weinstein, I.B. and Wigler, M. 1977 Cell culture studies provide new information on tumour promoters. Nature 270: 659-690. PDF
. Pellicer, A., Wigler, M., Axel, R. and Silverstin, S. 1978 The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell 14: 133-141. PMID: 208776 PDF
. Wigler, M., DeFeo, D. and Weinstien, I.B. 1978 Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. Cancer Res. 38: 1434-1437. PMID: 639070 PDF
. Wigler, M., Pellicer, A., Silverstein, S. and Axel, R. 1978 Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell 14: 725-731. PMID: 210957 PDF
. Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G. and Chasin, L. 1979 DNA mediated transfer of the APRT locus into mammalian cells. Proc. Natl. Acad. Sci. USA 76: 1373-1376. PMID: 286319 PDF
. Wigler, M., Sweet, R., Sim, G.K., Wold, B., Pellicer, A., Lacy, E., Maniatis, T., Silverstein, S., and Axel, R. 1979 Transformation of mammalian cells with genes from prokaryotes and eukaryotes. Cell 16: 777-785. PMID: 222468 PDF
. Wold, B., Wigler, M., Lacy, E., Maniatis, T., Silverstein, S., and Axel, R. 1979 Introduction and expression of the rabbit ?-globin gene in mouse fibroblasts. Proc. Natl. Acad. Sci. USA 76: 56-84. PMID: 293672 PDF
. Wigler, M., Perucho, M., Kurtz, D., Dana, S., Pellicer, A., Axel, R. and Silverstein, S. 1980 Transformation of mammalian cells with an amplifiable dominant acting gene. Proc. Natl. Acad. Sci. U.S., 77: 3567. PMID: 6251468 PDF
. Perucho, M., Hanahan, D., Lipsich, L. and Wigler, M. 1980 Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature 285: 207. PMID: 6246445 PDF
. Perucho, M., Hanahan, D. and Wigler, M. 1980 Genetic and physical linkage of exogenous sequences in transformed cells. Cell 22: 309-317. PMID: 6253083 PDF
. Hanahan, D., Lane, D., Lipsich, L., Wigler, M. and Botchan, M. 1980 Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell 21: 127-139. PMID: 6250708 PDF
. Perucho, M. and Wigler, M. 1981 Linkage and expression of foreign DNA in cultured animal cells. Cold Spring Harbor Symp. Quant. Biol., 45: 829-838. PMID: 6942952 PDF
. Wigler, M., Levy, D. and Perucho, M. 1981 The somatic replication of DNA methylation. Cell 24: 33-40. PMID: 6263490 PDF
. Wigler, M.H. 1981 The inheritance of methylation patterns in vertebrates. Cell, 24: 285-286. PMID: 7195315 PDF
. Perucho, M., Goldfarb, M., Shimizu, K., Lama, C., Fogh, J. and Wigler, M. 1981 Human-tumor-derived cell lines contain common and different transforming genes. Cell 27: 467-476. PMID: 6101201 PDF
. Goldfarb, M., Shimizu, K., Perucho, M. and Wigler, M. 1982 Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature 296: 404-409. PMID: 7063039 PDF
. Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., Wigler, M. 1982 Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature, 300: 762-765. PMID: 7177195 PDF
. Shimizu, K., Goldfarb, M., Perucho, M. Wigler, M., 1983 Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc. Natl. Acad. Sci., USA, 80: 383-387. PMID: 6300838 PDF
. Shimizu, K., Goldfarb, M., Suard, Y., Perucho, M., Li, Y., Kamata, T., Feramisco, J., Stavnezer, E., Fogh, J. and Wigler, M. 1983 Three human transforming genes are related to the viral ras oncogenes. Proc. Natl. Acad. Sci., USA 80: 2112-2116. PMID: 6300838 PDF
. Fasano, O., Taparowsky, E., Fiddes, J., Wigler, M. and Goldfarb, M. 1983 Sequence and structure of the coding regions of the human H- ras -1 gene from T24 bladder carcinoma cells. J. Mol. Appl. Genetics, 2: 173-180. PMID: 6308118 PDF
. Kwoh, T.J., Zipser, D. and Wigler, M. 1983 Mutational analysis of the cloned chicken thymidine kinase gene. J. Mol. Appl. Genetics, 2: 191-200. PMID: 6875426 PDF
. Barker, D., McCoy, M., Weinberg, R., Goldfarb, M., Wigler, M., Burt, R., Gardner, E. and White, R. 1983 A test of the role of two oncogenes in an inherited predisposition to colon cancer. Molecular Biology and Medicine, 1: 199-206. PMID: 6594558 PDF
. Taparowsky, E., Shimizu, K., Goldfarb M., and Wigler M., 1983 Structure and activation of the N- ras gene. Cell, 34: 581-586. PMID: 6616621 PDF
. Shimizu, K., Birnbaum, D., Ruley, M.A., Fasano, O., Suard, Y, Edlund, L., Taparowsky, E., Goldfarb, M. and Wigler, M. 1983 The structure of the Ki- ras gene of the human lung carcinoma cell line Calu-1. Nature, 304: 497-500. PMID: 6308465 PDF
. Ryan, J., Barker, P.E., Shimizu, K., Wigler, M., and Ruddle, F.H. 1983 Chromosomal assignment of a family of human oncogenes. Proc. Natl. Acad. Sci., USA 80: 4460-4463. PMID: 6576347 PDF
. Powers, S., Kataoka, T., Fasano, O., Goldfarb, M., Strathern, J., Broach, J., and Wigler, M. 1984 Genes in Saccharomyces cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell, 36: 607-612. PMID: 6365329 PDF
. Fasano, O., Aldrich, T., Tamanoi, F., Taparowsky, E., Furth, M., and Wigler, M. 1984 Analysis of the transforming potential of the human H- ras genes by random mutagenesis. Proc. Natl. Acad. Sci., 81: 4008-4012. PMID: 6308118 PDF
. Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J. and Wigler, M. 1984 Genetic analysis of yeast RAS1 and RAS2 genes. Cell, 37: 437-445. PMID: 6327067 PDF
. Fasano, O., Birnbaum, D., Edlund, L., Fogh, J. and Wigler, M. 1984 New human transforming genes detected by a tumorigenicity assay. Molecular and Cellular Biology, 4 : 1695-1705. PMID: 6092933 PDF
. Tamanoi, F., Walsh, M., Kataoka, T. and Wigler, M. 1984 A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proc. Natl. Acad. Sci. USA 81: 6924-6928. PMID: 6438624 PDF
. Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., and Wigler, M. 1985 Functional homology of mammalian and yeast RAS genes. Cell, 40: 19-26. PMID: 2981628 PDF
. Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K., and Wigler, M. 1985 In yeast, RAS proteins are controlling elements of the adenylate cyclase. Cell, 40: 27-36. PMID: 2981630 PDF
. Gross, M., Sweet, R., Sathe, G., Yokoyama, S., Fasano, O., Goldfarb, M., Wigler, M., Rosenberg, M. 1985 Purification and characterization of human H- RAS proteins produced in E . coli . Molecular Cellular Biology, 5: 1015-1024. PMID: 3923330 PDF
. Broek, D., Samily, N., Fasano, O., Fujiyama, A., Tamanoi, F., Northup, J., and Wigler, M. 1985 Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins. Cell, 41: 763-769. PMID: 3891097 PDF
. Kataoka, T., Broek, D. and Wigler, M 1985 DNA sequence and characterization of the S . cerevisiae gene encoding adenylate cyclase. Cell, 43 : 493-505. PMID: 2934138 PDF
. Birchmeier, C., Broek, D. and Wigler, M. 1985 RAS proteins can induce meiosis in Xenopus oocytes. Cell, 43: 615-621. PMID: 2416466 PDF
. Birchmeier, C., Broek, D., Toda, T., Powers, S., Kataoka T. and Wigler, M. 1985 Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposium on Quantative Biology, Volume L, pp. 721-725. PMID: 3007012 PDF
. Young, D., Waitches, G., Birchmeier, C., Fasano, O. and Wigler, M. 1986 Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell, 45: 711-719. PMID: 3708691 PDF
. Birchmeier, C., Birnbaum, D., Waitches, G., Fasano, O. and Wigler, M. 1986 Characterization of an activated human ros gene. Molecular Cellular Biology, 6: 3109-3116. PMID: 3785223 PDF
. Powers, S., Michaelis, S., Broek D., Anna-A., S.S., Field, J., Herskowitz, I. and Wigler, M. 1986 RAM , a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a -factor. Cell, 47: 413-422. PMID: 3533274 PDF
. Sass, P., Field, J., Nikawa, J., Toda, T. and Wigler, M. 1986 Cloning and characterization of the high affinity cAMP phosphodiesterase of S . cerevisiae . Proc. Natl. Acad. Sci., 83: 9303-9307. PMID: 3025832 PDF
. Birchmeier, C., Young, D. and Wigler, M. 1986 Characterization of two new human oncogenes. Cold Spring Harbor Symposium, vol LI: 993-1000. PMID: 3472773 PDF
. Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S. and Wigler, M. 1987 The S . cerevisiae CDC25 gene product regulates the RAS /adenylate cyclase pathway. Cell, 48: 789-799. PMID: 3545497 PDF
. Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McMullen, B., Murwitz, M., Krebs, E.G. and Wigler, M. 1987 Cloning and characterization of BCY1 , a locus encoding a regulatory subunit of the cyclic AMP dependent protein kinase in Saccharomyces cerevisiae. Molecular Cellular Biology, 7: 1371-1377. PMID: 3037314 PDF
. Field, J., Broek, D., Kataoka, T., and Wigler, M. 1987 Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Molecular Cellular Biology, 7: 2128-2133. PMID: 3299060 PDF
. Rabin, M., Birnbaum, D., Young, D., Birchmeier, C., Wigler, M. and Ruddle, F. 1987 Human ROS1 and MAS1 oncogenes are located in regions of chromosome 6 associated with tumor-specific rearrangements. Oncogene Research, 1: 169-178. PMID: 3329713 PDF
. Johnson, K.E., Cameron, S., Toda, T., Wigler, M. and Zoller, M. 1987 Expression in Escherichia coli of BCY1 , the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae . J. Biological Chemistry 262: 8636-8642. PMID: 3036817 PDF
. Toda, T., Cameron, S., Sass, P., M. Zoller and Wigler, M. 1987 Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP dependent protein kinase. Cell, 50: 277-287. PMID: 3036373 PDF
. Birchmeier, C., Sharma, S. and Wigler, M. 1987 Expression and rearrangement of the ros1 gene in human glioblastoma cells. Proc. Natl. Acad. Sci., 84: 9270-9274. PMID: 2827175 PDF
. Nikawa, J., Sass, P. and Wigler, M. 1987 Cloning and characterization of the low affinity cyclic AMP phosphodiestrase gene of S. cerevisiae . Molecular and Cellular Biology, 7: 3629-3636. PMID: 2824992 PDF
. Nikawa, J., Cameron, S., Toda, T., Ferguson, K.M., and Wigler, M. 1987 Rigorous feedback control of cAMP levels in S. cerevisiae . Genes and Development, 1: 931-937. PMID: 2828175 PDF
. Toda, T., Broek, D., Field, J., Michaeli, T., Cameron, S., Nikawa, J., Sass, P., Birchmeier, C., Powers, S. and Wigler, M. 1987 Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae. Oncogene and Cancer, S.A. Aaronson et al., (eds). Japan Sci. Soc. Press, Tokyo/VNU Sci. Press, pp. 253-260. PMID: 3290050 PDF
. Levin, L.R., Kuret, J., Johnson, K.E., Powers, S., Cameron, S., Michaeli, M., Wigler, M. and Zoller, M. 1988 A mutation in the catalytic subunit of the cAMP-dependent protein kinase that disrupts regulation. Science, 240: 68-70. PMID: 2832943 PDF
. Cameron, S., Levin, L., Zoller, M. and Wigler, M. 1988 cAMP-Independent control of sporulation, glycogen metabolism and heat shock resistance in S. cerevisiae . Cell 53: 555-566. PMID: 2836063 PDF
. Toda, T., Cameron, S., Sass, P and Wigler, M. 1988 SCH9 , a gene of S. cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP dependent protein kinase catalytic Subunits . Genes and Development, 2: 517-527. PMID: 3290050 PDF
. Field, J., Nikawa, J., Broek, D., MacDonald, B., Rodgers, L., Wilson, I.A., Lerner, R.A. and Wigler, M. 1988 Purification of a RAS -responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Molecular and Cellular Biology, 8: 2159-2165. PMID: 2455217 PDF
. Young, D., O'Neill, K., Jessell, T. and Wigler, M. 1988 Characterization of the rat mas oncogene and its high level expression in the hippocampus and cerebral cortex of rat brain. Proc. Natl. Acad. Sci., 85: 5339-5342. PMID: 2455902 PDF
. Wigler, M., Field, J., Powers, S., Broek, D., Toda, T., Cameron, S., Nikawa, J., Michaeli, T., Colicelli, J., and Ferguson, K. 1988 Studies of RAS function in the yeast S. Cerevisiae . Cold Spring Harbor Symposium, vol. LIII, pages 649-655. PMID: 3076094 PDF
. Powers, S., O'Neill, K. and Wigler, M. 1989 Dominant Yeast and Mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in S. cerevisiae . Molecular and Cellular Biology, 9 : 390-395. PDF
. Colicelli, J., Birchmeier, C., Michaeli, T., O'Neill, K., Riggs, M. and M. Wigler 1989 Isolation and characterization of a mammalian gene encoding a high affinity cAMP phosphodiesterase. Proc. Natl. Acad. Sci., 86: 3599-3603. PDF
. Sharma, S., Birchmeier, C., Nikawa, J., O'Neill, K., Rodgers, L. and Wigler, M. 1989 Characterization of the ros1 -gene products expressed in human glioblastoma cell lines. Oncogene Research, 5: 91-100. PDF
. Michaeli, T., Field, J., Ballester, R., O'Neill, K. and Wigler, M. 1989 Mutants of H- ras which interfere with RAS effector function in S. Cerevisiae. EMBO J., 8: 3039-3044. PMID: 2684634 PDF
. Ballester, R., Michaeli, T., Ferguson, K., Xu, H-P., McCormick, F. and Wigler, M. 1989 Genetic analysis of mammalian GAP expressed in yeast. Cell 59: 681-686. PMID: 2684416 PDF
. Young, D., Riggs, M., Field, J., Vojtek, A., Broek, D., and Wigler, M. 1989 The adenylyl cyclase gene from schizosaccharomyces pombe. Proc. Natl. Acad. Sci., 86: 7989-7993. PDF
. Field, J. Xu, H-P, Michaeli, T., Ballester, R., Sass, P., Wigler, M., Colicelli, J. 1990 Mutations of the adenylyl Cyclase gene that block RAS function in Saccharomyces Cerevisiae. Science, 247: 464-467. PMID: 2405488 PDF
. Field, J., Vojtek, A., Ballester, R., Bolger, G., Colicelli, J., Ferguson, K., Gerst, J., Kataoka, T., Michaeli, T., Powers, S., Riggs, M., Rodgers, L., Wieland, I., Wheland, B. and Wigler, M. 1990 Cloning and characterization of CAP , the Saccharomyces cerevisiae gene encoding the 70 kDa adenylyl cyclase associated protein. Cell, 61 : 319-327. PDF
. Weiland, I., Bolger, G., Asouline, G. and Wigler, M. 1990 A method for difference cloning: Gene amplification following subtractive hybridization. Proc. Natl. Acad. Sci., 87 : 2720-2724. PMID: 2138783 PDF
. Colicelli, J., Field, J., Ballester, R., Chester, N., Young, D., and Wigler, M. 1990 Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Mol. Cell. Biol., 10: 2539-2543. PMID: 2111437 PDF
. Birchmeier, C., O'Neill, K., Riggs, M., and Wigler, M. 1990 Characterization of ROS1 cDNA from a human glioblastoma cell line. Proc. Natl. Acad. Sci. USA 87: 4799-4803. PMID: 2352949 PDF
. Wigler, M. 1990 GAPs in understanding Ras. Nature, 346: 696-7. PMID: 2201920 PDF
. Xu, H.-P., Riggs, M., Rodgers, L., and Wigler, M. 1990 A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. Nucl. Acid Res. 18: 5304. PMID: 2205842 PDF
. Xu, H-P., Wang, Y., Riggs, M., Rodgers, L. and Wigler, M. 1990 Biological activity of the mammalian RAP genes in Yeast. Cell Regulation, 1: 763-769. PMID: 1983087 PDF
. Ballester, R., Marchuk, D., Boguski, M., Saulino, A., Letcher, R., Wigler, M. and Collins, F. 1990 The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell, 63: 851-859. PMID: 2121371 PDF
. Gerst, J., Ferguson, K., Vojtek, A., Wigler, M. and Field, J. 1991 CAP: A bifunctional component of the S. cerevisiae adenylyl cyclase complex. Mol. Cell. Biol., 11: 1248-1257. PMID: 1996090 PDF
. Kawamukai, M., Ferguson, K., Wigler, M. and Young, D. 1991 Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regulation, 2: 155-164. PMID: 1863602 PDF
. Colicelli, J., Birchmeier, C., Rodgers, L., Riggs, M. and Wigler, M. 1991 Expression of three mammalian cDNAs which interfere with RAS function in S. cerevisiae. Proc. Natl. Acad. Sci. USA, 88: 2913-2917. PMID: 1849280 PDF
. Young, D., O'Neill, K., Broek, D. and Wigler, M. 1991 The adenylyl cyclase gene from Saccharomyces Kluyveri. Gene, 102: 129-132. PMID: 1864503 PDF
. Wang, Y., Xu, H.-P., Riggs, M., Rodgers, L. and Wigler, M. 1991 Byr2 , an S. pombe gene encoding a protein kinase capable of partial phenotypic suppression of ras1 - strains. Mol. Cell. Biol., 11: 3554-3563. PMID: 1883874 PDF
. Wang, Y., Boguski, M., Riggs, M., Rodgers, L. and Wigler, M. 1991 Sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation, 2: 453-465. PMID: 2046669 PDF
. Daar, I., Nebreda, A.R., Yew, N., Sass, P., Paules, R., Santos, E., Wigler, M. and Vande Woude, G.F. 1991 The ras oncoprotein and M-phase activity. Science, 253: 74-76. PMID: 1829549 PDF
. Vojtek, A., Haarer, B., Field, J., Gerst, J., Pollard, T.D., Brown, S. and Wigler, M. 1991 Evidence for a functional link between profilin and CAP in the yeast Saccharomyces cerevisiae . Cell, 66: 497-505. PMID: 1868547 PDF
. Xu, H.-P., Jung V., Riggs M., Rodgers L. and Wigler M. 1992 A gene encoding a protein with seven zinc finger domains which acts on the sexual differentiation pathways of Schizosaccharomyces pombe. Molecular Biology of the Cell, 3: 721-734. PMID: 1515675 PDF
. Gerst, J., Rodgers L., Riggs M. and Wigler M. 1992 SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: Genetic interactions with the RAS and CAP genes. Proc. Natl. Acad. Sci. USA, 89: 4338-4342. PMID: 1316605 PDF
.Kawamukai, M., Gerst, J., Field, J., Riggs, M., Rodgers, L., Wigler, M. and Young, D. 1992 Genetic and biochemical analysis of the adenylyl cyclase-associated protein, CAP, in Schizosaccharomyces pombe. Molecular Biology of the Cell, 3: 167-180. PMID: 1550959 PDF
. Shibuya, E.K., Polverino, A.J., Chang, E., Wigler, M. and Ruderman, J.V. 1992 Oncogenic Ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc. Natl. Acad. Sci. USA, 89: 9831-9835. PMID: 1384061 PDF
. Andersen, L.B., Ballester, R., Marchuk, D.A. Chang, E., Gutmann, D.H., Saulino, A.M., Camonis, J., Wigler, M. and Collins, F.S. 1993 A conserved alternative splice in the von Recklinghausen neurofibromatosis ( NF1 ) gene produces two neurofibromin isoforms, both with GAP activity. Mol. Cell. Biol. 13: 487-495. PMID: 8437860 PDF
. Gutmann, D.H., Boguski, M., Marchuk, D., Wigler, M., Collins, F.S. and Ballester, R. 1993 Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. Oncogene, 8: 761-769. PMID: 8437860 PDF
. Michaeli, T., Bloom, T., Martins, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J., and Wigler, M. 1993 Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase deficient S. cerevisiae . J. Biological Chemistry, 268 : 12925-12932. PMID: 8438152 PDF
. Neiman, A.M., Stevenson, B.J., Xu, H-P., Sprague, G.F. Jr., Herskowitz, I., Wigler, M., and Marcus, S. 1993 Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Mol. Biol. of the Cell 4: 107-120. PMID: 8443406 PDF
. Lisitsyn, N., Lisitsyn, N. and Wigler, M. 1993 Cloning the differences between two complex genomes. Science 259: 946-951. PMID: 8438152 PDF
. Van Aelst, L., Barr, M., Marcus, S., Polverino, A. and Wigler, M. 1993 Complex formation between RAS and RAF and other protein kinases. Proc. Natl. Acad. Sci. USA, 90 : 6213-6217. PMID: 8327501 PDF
. Chardin, P., Camonis, J.H., Gale, N.W., Van Aelst, L., Schlessinger, J., Wigler, M. and Bar-Sagi, D. 1993 A human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science, 260: 1338-1343. PMID: 8493579 PDF
. Bolger, G., Michaeli, T., Martins, T., St. John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M. and Ferguson, K. 1993 A family of human phosphodiesterases homologous to the Dunce learning and memory gene of Drosophila melanogaster are potential targets for anti-depressant drugs. Molecular and Cellular Biology, 13: 6558-6571. PMID: 8413254 PDF
. Ohlmeyer, M.H.J., Swanson, M.N., Dillard, L.W., Reader, J.C., Asouline, G., Kobayashi, R., Wigler, M., Still, W.C. 1993 Complex synthetic chemical libraries indexed with molecular tags. Proc. Natl. Acad. Sci. USA, 90: 10922-10926. PMID: 7504286 PDF
. Lisitsyn, N.A., Segre, J.A., Kusumi, K., Lisitsyn, N.M., Nadeau, J.H., Frankel, W.N., Wigler, M. and Landers, E.S. 1994 Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nature Genetics, 6: 57-63. PMID: 8136836 PDF
. Xu, Hao-Peng, White, M., Marcus, S. and Wigler, M. 1994 Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe . Molecular and Cellular Biology, 14: 50-58. PMID: 8264618 PDF
. Jung, V., Wei, W., Ballester, R., Camonis, J., Mi, S., Van Aelst, L., Wigler, M. and Broek, D. 1994 Two types of ras mutants that dominantly interfere with activators of RAS. Mol. Cell. Biol. 14: 3707-3718. PMID: 8196614 PDF
. Marcus, S., Barr, M., Polverino, A., and Wigler, M. 1994 Complexes between STE5 and components of the yeast pheromone-responsive MAP kinase module. Proc. Natl. Acad. Sci. USA, 91: 7762-7766. PMID: 8052657 PDF
. Chang, E., Barr, M., Wang, Y., Jung, V., Xu, H.-P., and Wigler, M. 1994 Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell, 79: 131-141. PMID: 7923372 PDF
. Lisitsyn, N.A., Lisitsina, N.M., Dalbagni, G., Barker, P., Sanches, C.A. Gnarra, J., Linehan, W.M. Reid, B.J. and Wigler, M. 1995 Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proc. Natl. Acad. Sci. USA, 92: 151-155. PMID: 7816807 PDF
. White, M., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. and Wigler, M. 1995 Multiple RAS functions can contribute to mammalian cell transformation. Cell, 80: 533-541. PMID: 7867061 PDF
. Jung, V., Chen, Li, Hofmann, S.L., Wigler, M., Powers, S. 1995 Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block attachment and palmitoylation of Ras proteins. Mol. Cel. Biol. 15: 1333-1342. PMID: 7532279 PDF
. Van Aelst, L., White, M. and Wigler, M. 1994 Ras partners. Cold Spring Harbor Symposium on Quantative Biology, Volume 59: pp. 181-186. PDF
. Lisitsyn, N.A., Leach, F.S., Vogelstein, B. and Wigler, M. 1995 Detection of genetic loss in tumors by representational difference analysis. Cold Spring Harbor Symposium on Quantative Biology, Volume 59: pp. 585-587. PMID: 7587116 PDF
. Marcus, S., Polverino, A., Chang, E., Robbins, D., Cobb, M.H., Wigler, M. 1995 Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast, Schizosaccharomyces pombe . Proc. Natl. Acad. Sci. USA, 92: 6180-6184. PMID: 7597098 PDF
. Joneson, T., White, M.A., Wigler, M.H. and Bar-Sagi, D. 1996 Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science 271: 810-812. PMID: 8628998 PDF
. Thiagalingam, S., Lisitsyn, N.A., Hamaguchi, M., Wigler, M.H., Willson, J.K.V., Markowitz, S.D., Leach, F.S., Kinzler, K.W., Vogelstein, B. 1996 Evaluation of the FHIT gene in colorectal Cancers. Cancer Research, 56: 2936-2939. PMID: 8674044 PDF
. Khosravi-Far, R., White, M.A., Westwick, J.K., Solski, P.A., Chrzanowska-Wodnicka, M., Van Aelst, L., Wigler, M., Der, C.J. 1996 Oncogenic Ras activation of Raf/mitogen-activation protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol. Cell. Biol. 16: 3923-3933. PMID: 8668210 PDF
. Barr, M.M., Tu, H., Van Aelst, L., Wigler, M. 1996 Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Mol. Cell. Biol. 16: 5597-5603. PMID: 8816472 PDF
. White, M.A., Vale, T., Camonis, J.H., Schaefer, E., Wigler, M.H. 1996 A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J. Biol. Chem., 271: 16439-16442. PDF
. Xu, H.-P., Yanak, B.L., Wigler, M.H., and Gorin, M.B. 1996 New polymorphic markers in the vicinity of the pearl locus on mouse Chromosome 13. Mammalian Genome, 7: 16-19. PDF
. Li, J., Yen, C., Liaw, D., Podsypanina,K., Bose, S., Wang, S., Puc, J., Miliarcsis, C., Rodgers, L., McCombie, R., Bigner, S.H., Giovanella, C., Ittman, M., Tycko, B., Hibshoosh, H., Wigler, M.H. and Parsons, R. 1997 PTEN a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275: 1943-1947. PMID: 9072974 PDF
. Myers, M.P., Stolarov, J.P., Eng, C., Li, J., Wang, S.I., Wigler, M., Parsons, R. and Tonks, N.K. 1997 P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci., USA 94: 9052-9057. PMCID: PMC23024 PDF
. Tu, H., Barr, M., Dong, D.L. and Wigler, M. 1997 Multiple regulatory domains on the Byr2 protein kinase. Mol. Cell. Biol., 17: 5876-5887. PMID: 9315645 PDF
. Hamaguchi, M., O'Connor, E.A., Chen, T., Parnell, L., McCombie, R.W., and Wigler, M. 1998 Rapid isolation of cDNA by hybridization. Proc.Natl.Acad.Sci. 95: 3764-3769. PMCID: PMC19911 PDF
. Lucito, R., Nakamura, M., West, J.A., Han, Y., Chin, K., Jensen, K., McCombie, R., Gray, J.W., and Wigler, M. 1998 Genetic analysis using genomic representations. Proc.Natl.Acad.Sci.USA 95: 4487-4492. PMCID:22516 PDF
. Webb, C.P., Van Aelst, L., Wigler, M.H. and Vande Woude, G.F. 1998 Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc. Natl. Acad. Sci. USA 95: 8773-8778. PMCID: PMC21152 PDF
. Myers, M., Pass, I., Batty, I.H., Van der Kaay, J., Stolarov, J.P., Hemmings, B.A., Wigler, M.H., Downes, C.P., Tonks, N.K. 1998 The lipid phosphatase activity of PTEN is critical for its tumor suppressor function. Proc. Natl. Acad. Sci. USA, 95: 13513-13518. PMCID: PMC24850 PDF
. Tu, H. and Wigler, M. 1999 Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol. Cell. Biol., 19: 602-611. PMID: 9858584 PDF
. Dong, D.L., Liu, R., Sherlock, R., Wigler, M., Nestler, P.H. 1999 Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxy-terminus. Chem. & Biol., 6: 133-141. PMID: 10074468 PDF
. Lucito, R., West, J., Reiner, A., Alexander, J., Esposito, D., Mishra, B., Powers, S., Norton, L., and Wigler, M. 2000 Detecting gene copy number fluctuations in tumor cells by microarray analyis of genomic representations. Genome Research, 10: 1726-1736. PMCID: PMC310939 PDF
. Wen, S., Stolarov, J., Myers, M.P., Su, J.D., Wigler, M.H., Tonks, N.K., and Durden, D.L. 2001 PTEN controls tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA, 98: 4622-4627. PMCID: PMC31884 PDF
. Casey, W., Mishra, B. and Wigler, M. 2001 Placing probes along the genome using pairwise distance data. Algorithms in Bioinformatics, O. Gasscuel and B.M.E. Moret (eds.): First International Workshops, Arhus, Denmark. Springer-Verlag Berlin Heidelberg WABI 2001, LNCS, 2149: 52-68. PDF
. Stolarov, J., Chang, K., Reiner, A., Rodgers, L., Hannon, G.J., Wigler, M. and Mittal, V. 2001 Design of a retroviral-mediated ecdysone inducible system an its application to the expression profiling of the PTEN tumor suppressor. Proc. Natl. Acad. Sci., 98: 13043-13048. PMCID: 60821 PDF
. Scheffzek, K., Grünewald, P., Wohlgemuth, S., Kabsch, W., Tu, H., Wigler, M., Wittinghofer, A., Herrmann, C. 2001 The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure, 9: 1043-1050. PMID: 11709168 PDF
. Wigler, M. and Mishra, B. 2002 Wild by Nature. Science, 296: 1408-1408. PMID: 12029116 PDF
. Hamaguchi, M., Meth, J.L., von Klitzing, C. Wei, W., Esposito, D., Rodgers, L. Walsh, T., Welch, P., King, M-C. and Wigler, M.H. 2002 DBC2, a candidate for a tumor suppressor gene involved in breast cancer Proc. Natl. Acad. Sci., USA 99: 13647-13652. PMCID: PMC129730 PDF
. Mu, D., Chen, L., Zhang, X., See, L-H., Koch, C.M., Yen, C., Tong, J.J., Spiegel, L., Nguyen, K.C.Q., Servoss, A., Peng, Y., Pei, L., Marks, J.R., Lowe, S., Hoey, T., Jan, L.Y., McCombie, W.R., Wigler, M.H., Powers, S. 2003 Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell, 3: 297-302. PMID: 12676587 PDF
. Lucito, R., Healy, J., Alexander, J., Reiner, A., Esposito, D., Chi, M., Rodgers, L., Brady, A., Sebat, J., Troge, J., West, J., Rostan, S., Nguyen, K.C.Q., Powers, S., Ye, K.Q., Olshen, A., Venkatraman, E., Norton, L. and Wigler, M. 2003 Representational oligonucleotide microarray analysis: a high –resolution method to detect genome copy number variation. Genome Research 13: 2291-2305. PMCID: PMC403708 PDF
. Healy, J., Thomas, E., Schwartz, J.T. and Wigler, M. 2003 Annotating large genomes with exact word matches. Genome Research 13: 2306-2315. PMCID: PMC403711 PDF
. Thomas, E.E., Srebro, N., Sebat, J., Navin, N., Healy, J., Mishra, B., and Wigler, M. 2004 Distribution of short, paired duplications in mammalian genomes. Proc. Natl. Acad. Sci., USA, 101: 10349-10354. PMCID: PMC478600 PDF
. Sebat, J., Muthuswamy, L., Troge, J., Alexander, J., Young, J., Lundin, P., Maner, S., Massa, H., Walker, M., Chi, M., Navin, N., Lucito, R., Healy, J., Hicks, J., Ye, K., Reiner, A., Gilliam, T.C., Trask, B., Patterson, N., Zetterberg, A., Wigler, M. 2004 Large-Scale Copy Number Polymorphism in the Human Genome. Science, 305: 525-528. PMID: 15273396 PDF
. Olshen, A., Venkatraman, E.S., Lucito, R., and Wigler, M. 2004 Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics, 5: 557-572. PMID: 15475419 PDF
. Daruwala, R.-S, Rudra, A., Ostrer, H., Lucito, R., Wigler, M. and Mishra, B. 2004 A versatile statistical analysis algorithm to detect genome copy number variation. Proc. Natl. Acad. Sci., 101: 16292-16297. PMCID: PMC528962 PDF
. Jobanputra, V., Sebat, J., Chung, W., Anyane-Yeboa, K., Wigler, M. and Warburton, D. 2004 Application of ROMA (Representational Oligonucleotide Microarray Analysis) to patients with known cytogenetic rearrangements. Genetics in Medicine, 7: 111-118. PMID 15714078 PDF
. West, J., Healy, J., Casey, W., Mishra, B., and Wigler, M. 2006 Validation of S. Pombe Sequence Assembly by Micro-Array Hybridization. Journal of Computational Biology 13: 1-20. PMID: 16740623 PDF
. Lakshmi, B., Hall, I.M., Egan, C., Alexander, J., Leotta, A., Healy, J., Zender, L., Spector, M., Xue, W., Lowe, S.W., Wigler, M. and Lucito, R. 2006 Mouse genomic Representational Oligonucleotide Microarray Analysis: detection of copy number variations in normal and tumor. Proc. Natl. Acad. Sci. USA 103: 11234-11239. PMCID: PMC1544071 PDF
. Navin, N., Grubor, V., Hicks, J., Leibu, E., Thomas, E., Troge, J., Riggs, M., Lundin, P., Maner, lS., Sebat, J., Zetterberg, A. and Wigler, M. 2006 Prober: Oligonucleotide FISH probe design software. Bioinformatics, 22: 2437-2438. PDF
. Zender, L., Spector, M.S., Xue, W., Flemming, P., Cardon-Cardo, C., Silke, J., Fan, S-T., Luk, J.M., Wigler, M., Hannon, G.J., Mu, D., Lucito, R., Powers, S., and Lowe, S. 2006 Identification and validation of onogenes in liver cancer using an integrative approach. Cell 125: 1253-1267. PMID: 16814713 PDF
. Hicks, J., Krasnitz,A., Lakshmi, B., Navin, N., Riggs, M., Leibu, E., Esposito, D., Alexander, J., Troge, J., Grubor,V., Yoon, S., Wigler, M., Ye, K., Børresen-Dale, A-L., Naume, B., Schlicting, E., Norton, L., Hagerstrom, T., Skoog, L., Auer G., Maner, S., Lundin, P., and Zetterberg, A., 2006 Novel Patterns of genomic rearrangement and their association with survival in breast cancer. Genome Research 16:1465–1479. PMCID: PMC1665631 PDF
. Pelham, R.J., Rodgers, L., Hall, I., Lucito, R., Nquyen, K.C.Q., Navin, N., Hicks, J., Mu, D., Powers, S., Wigler, M. and Botstein, M. 2006 Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proc. Natl. Acad. Sci. USA 103: 19848-19853. PMCID: PMC1698871 PDF
. Sebat, J., Lakshmi, B., Malhotra, D., Lese-Martin, C., Troge, J., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., Leotta, A., Pai, D., Zhang, R., Lee, Y-H., Hicks, J., Spence, S.J., Lee, A.T., Puura, K., Lehtimäki, T., Ledbetter, D., Gregersen, P.K., Bregman, J., Sutcliffe, J.S., Jobanputra, V., Chung, W., Warburton, D., King, M-C., Skuse, D., Geschwind, D.H., Gilliam, T.C., Ye, K., Wigler, M. 2007 Strong association of de novo copy number mutations with autism. Science 316: 445-449. PMID: 17363630 PDF
. Zhao, X., Leotta, A., Qiu, S., Kustanovich, V., Lajonchere, C., Geschwin, D.H., Lord, C., Sebat, J., Ye., K. and Wigler, M. 2007 A unified genetic theory for sporadic and inherited autism. Proc. Natl. Acad. Sci., USA 104: 12831-12836. PMCID: PMC1933261 PDF
. Egan, C.M., Sridhar, S., Wigler, M., Hall, I.M. 2007 Recurrent DNA copy number variation in the laboratory mouse. Nat. Genet., 39: 1384-1389. PMID: 17965714 PDF
. Lucito, R., Suresh, S., Walter, K., Pandey, A., B. Lakshmi, Krasnitz, A., Sebat, J., Wigler, M., Klein, A.P., Brune, K., Palmisano, E., Maitra, A., Goggins, M., and Hruban, R.H. 2007 Copy-Number Variants in Patients with a Strong Family History of Pancreatic Cancer. Cancer Biol Ther. 6(10) 1592-9. PMID: 17912030 PDF
. Alarcon, M., Abrahams, B.S., Stone, J.L., Duvall, J.A., Perederiy, J.V., Bomar,J.M., Sebat, J., Wigler, M., Martin, C.L., Ledbetter, D.H., Nelson, S.F., Cantor, R.M., Geschwind, D.H. 2008 Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am J. Hum. Genet., 82: 150-159. PMCID: PMC2253955 PDF
. Xue, W., Krasnitz, A., Lucito, R., Sordella, R., VanAelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M., Powers, S., Zender, L., Lowe, S.W. 2008 DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes Dev 22: 1439-1444. PMCID: PMC2418580 PDF
. Grubor, V., Krasnitz, A., Troge, J.E., Meth,J.L., Lakshmi, B., Kendall, J.T., Yamrom, B., Alex, G., Pai, D., Navin, N., Hufnagel, L.A., Lee, Y-H., Cook, K., Allen, S., Rai, K.R., Damle, R.N., Calissano, C., Chiorazzi, N., Wigler, M. and Esposito, D. 2008 Novel genomic alterations and clonal evolution in Chronic Lymphosytic Leukemia revealed by Representational Oligonucleotide Microarray Analysis (ROMA). Blood, 113: 1294-1303. PMID: 18922857 PDF
. Zender, L., Xue, W., Zuber, J., Semighini, C.P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J.M., Schirmacher, P., McCombie, R.W., Wigler, M., Hicks, J., Hannon, G.J., Powers, S., Lowe, S.W. 2008 An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell 135: 852-864. PMID: 19012953 PDF
. Hodges, E., Smith, A.D., Kendall, J., Xuan, Z., Ravi, K., Rooks, M., Zhang, M.Q., Ye, K., Bhattacharjee, A., Brizuela, L., McCombie, R., Wigler, M., Hannon, G.J. and Hicks, J. 2009 High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Research, 19: 1593-1605. PMCID: PMC2752124 PDF
. Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. 2009 Functional Identification of tumor-suppressor genes through an in vivo RNA interference screen in a muse lymphoma mode. Cancer Cell. 16:324-35. PMCID: PMC2829755 PDF
. Navin, N., Krasnitz, A., Rodgers, R., Cook, K., Meth, J., Kendall, J., Riggs, M., Eberling, Y., Troge, J., Grubor, V., Levy, D., Lundin, P., Månér, S., Zetterberg, A., Hicks, J. and Wigler, M. 2010 Inferring tumor progression from genomic heterogeneity. Genome Research, 20: 68-80. PMCID: PMC2798832. PDF
. Russnes, H.G., Moen Vollan, H.K., Lingjærde, O.C., Krasnitz, A., Lundin, P., Naume, B., Sørlie, T., Borgen, E., Rye., I.H., Langerød, A., Chin, S-F., Teschendorff, A.E., Stephens, P.J., Susanne Månér, S., Schlichting, E., Baumbusch, L.O., Kåresen, R., Stratton, M.P., Wigler, M., Caldas, C., Zetterberg, A., James Hicks, J., Børresen-Dale, A.-L. 2010 Genomic architecture characterizes tumor progression paths and fate in breast cancer patients. Science: Translational Medicine, 2: 38ra47. PMCID: 20592421 PDF
. Kamalakaran, S., Vinay Varadan, V., Giercksky Russnes, H.E., Levy, D., Kendall, J., Janevski, A., Riggs, M., Banerjee, N., Synnestvedt, M., Schlichting, E., Kåresen, R., Karensen, R., Shama Prasada, K., Rotti, H., Rao, R., Rao, L., Eric Tang, M.H., Satyamoorthy, K., Lucito, R., Wigler, M., Dimitrova, N., Naume, B., Borresen-Dale, A.-L., Hicks, J.B. 2011 DNA methylation patterns in luminal breast cancer differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Molecular Oncology, 5: 77-92. PMCID: 21169070 PDF
. Navin, N., Kendall, J., Troge, J., Andrews, P., Rodgers, L., McIndoo, J., Cook, K., Stepansky, A., Levy, D., Esposito, D., Muthuswamy, L., Krasnitz, A., McCombie, R., Hicks, J., Wigler, M. 2011 Tumor evolution inferred by single cell sequencing. Nature, 472: 90-94. PMID: 21399628 PDF
. Horev, G., Ellegood, J., Lerch, J.P., Son, Y.E., Muthuswamy, L., Vogel, H., Krieger, A.M., Buja, A., Henkelman, R.M., Wigler, M., Mills, A.A. 2011 Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc. Natl. Acad. Sci., USA, 108: 17076-17081. PMCID: 3193230 PDF
. Levy, D., Ronemus, M., Yamrom, B., Lee, Y-H., Leotta, A., Kendall, J., Marks, S., Lakshmi, B., Pai, D., Ye, K., Buja, A., Krieger, A., Yoon, S., Troge, J., Rodgers, L., Iossifov, I., Wigler, M. 2011 Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron, 70: 886-897. PMID: 21658582 PDF
. Gilman, S.R., Iossifov, I., Levy, D., Ronemus, M., Wigler, M., and Vitkup, D. 2011 Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron 70, 898-907. PMID: 21658583 PDF
. Lee, Y-H., Ronemus, M., Kendall, J., Lakshmi, B., Leotta, A., Levy, D., Esposito, D., Grubor, V., Ye, K., Wigler, M., and Yamrom, B. 2012 Reducing system noise in copy number data using principal components of self-self hybridizations. Proc. Natl. Acad. Sci., USA, 109: E103-E110. PDF
. Baslan, T., Kendall, K., Rodgers, L., Cox, H., Riggs, R., Stepansky, A., Troge, J., Kandasamy, R., Esposito, D., B. Lakshmi, Wigler, M., Navin, N., and Hicks, J. 2012 Genome wide copy number analysis of single cells. Nature Protocols, 7: 1024-1041. PDF
. Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y-H., Narzisi, G., Leotta, A., Kendall, J., Grabowska, E., Ma, B., Marks, S., Rodgers, L., Stepansky, A., Troge, J., Andrews, Bekritsky, M., Pradhan, K., Ghiban, E., Kramer, M., Parla, J., Demeter, R., Fulton, L., Fulton, R.S., Magrini, V.J., Ye, K., Darnell, J.C., Darnell, R.B., Mardis, E.R., Wilson, R.K., Schatz, M.C., McCombie, W.R., Wigler, M. 2012 De novo gene disruptions in children on the autistic spectrum. Neuron, 74: 285-299. PDF
. Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, A.R., Simon, J., Zhang, J., Luo, W., Hicks, J., Zender, L., Wang, X-W., Powers, S., Wigler, M., Lowe, S.W. 2012 A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proc. Natl. Acad. Sci., USA, 109: 8212-8217. PMID: 22566646. PDF
. Stadler, Z.K., Esposito, D., Shan, S., Vijai, J., Yamrom, B., Levy, D., Lee, Y-H., Kendallo, J., Leotta, A., Ronemus, M., Hansen, N., Sarrel, K.,Rauy-Murthy, R., Schrader, K., Kauff, N., Klein, R.J., Lipkin, S.M., Murali, R., Robson, M., Sheinfeld, J., Feldman, D., Bosl, G., Norton, L., Wigler, M., and Offit, K. 2012 Rare De Novo germline copy-number variation in testicular cancer. The American Journal of Human Genetics, 91: 379-383. PDF
. Wigler, M. 2012 Broad applications of single-cell nucleic acid analysis in biomedical research. Genome Medicine 2012, 4:79 PDF
. Krasnitz, A., Sun, G., Andrews, P., Wigler, M. 2013 Target inference from collections of genomic intervals. Proc. Natl. Acad. Sci., USA, 110: E2271-E2778 PDF
. Donnenberg, A.D., Hicks, J.B., Wigler, M., and Donnenberg, V.S. 2013 The cancer stem cell: Cell type or cell state? Cytometry, A 83, 5-7. PDF
. Shi, J. Whyte, W.A., Zepeda-Mendoza, C.J., Milazzo, J.P., Shen, C., Roe, J-S., Minder, J.L., Mercan, F., Wang, E., Eckersley-Maslin, M.A., Campbell, A.E., Kawaoka, S., Shareef. S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R.G., Wigler, M.H., Blobel, G.A., Zuber, J., Spector, D.L., Young, R.A., Vakoc, C.R. 2014 Role of SWI/SNF in acute leukemia maintenance and enhanced-mediated Myc regulation. Genes & Development 27: 2648-2662. PDF
. Ronemus, M., Iossifov, I., Levy, D. Wigler, M. 2014 The role of de novo mutation in the genetics of autism spectrum disorders. Nature Reviews Genetics, 15: 133-141. PDF
. Warburton, D., Ronemus, M., Kline, J., Jobanputra, V., Williams, I., Anyane-Yeboa, K., Chung, W., Yu, L., Wong, N., Awad, D., Yu, C-y., Leotta, A., Kendall, J., Yamrom, B., Lee, Y-h., Wigler, M., Levy, D. 2014 The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease. Hum. Genet., 133: 11-27. PDF
. Dago, A.E., Stepansky, A., Carlsson, A., Luttgen, M., Kendall, J., Baslan, T., Kolatkar, A., Wigler, M., Bethel, K., Gross, M.E., Hicks, J., Kuhn, P. 2014 Rapid Phenotypic and Genomic Change in Response to Therapeutic Pressure in Prostate Cancer Inferred by High Content Analysis of Single Circulating Tumor Cells. PLOS One, 9: e101777. PMCID 4118839. PDF
.Narzisi, G., O'Rawe, J.A., Iossifov, I., Fang, H., Lee, Y-pH., Wang, Z., Weu, Y., Lyon, G.J., Wigler, M., Schatz, M.C. 2014 Accurate de novo and Transmitted Indel Detection in Exome-Capture Data Using Microassembly. Nature Methods, 11: 1033-1036. PMCID 4180789. PDF
. Levy, D. and Wigler, M. 2014 Facilitated Sequence Counting and Assembly by Template Mutagenesis. Proc. Natl. Acad. Sci., USA, 111: E4632-4637. PMCI4217440. PDF
. Iossifov, I., O'Roak, B.J., Sanders, S., Ronemus, M., Krumm, N., Levy, D., Stessman, H., Withersoon, K., Vives, L., Patterson, K., Smith, J., Paeper, B., Nickerson, D.A., Dea, J., Dong, S., Gonzalez, L.E., Mandell, J.D., Mane, S.M., Murtha, M.T., Sullivan, C.A., Walker, M.F., Waqar, Z., Wei, L., Willsey, A.J., Yamrom, B., Lee, Y-h., Grabowska, E., Dalgic, E., Wang, Z., Marks, S., Anders, P., Leotta, A., Kendall, J., Hakker, I., Rosenbaum, J., Ma, B., Rodgers, L., Troge, J., Narzisi, G., Yoon, S., Schatz, M.C., Ye, K., McCombie, W.R., Shendure, J., Eichler, E.E., State, M.W. and Wigler, M. 2014 The contribution of de novo coding mutations to austism spectrum disorder. Nature, 515: 216-221. PDF
. Rye, I.H., Ludin, P., Maner, S., Fjellda, R., Naume, B., Wigler, M., Hicks, J., Borresen-Dale, A., Zetterberg, A., Russnes, H.G. 2014 Quantitative mutigene FISH on breast carcinomas identified der (1;16) (q10;p10) as an early event in luminal A tumors. Genes Chromosomes Cancer, 54: 235-248. PMCID: 4369137 PDF
. Jayaprakash, A.D., Benson, E.K., Gone, S., Liang, R., Shim, J., Lamvertini, L., Toloue, M.M., Wigler, M., Aaronson, S.A., Sachidanandam, R. 2015 Stable Heteroplasmy at the single-cell lese in facilitated by intercellular exchange of mtDNA. Nucleic Acids Research, 43: 2177-2178. PMCID: 4344500. PDF
. Baslan, T., Kendall, J., Ward, B., Cox, H., Leotta, A., Rodgers, L., Riggs, M., D’Italia, S., Sun, G., Yong, M., Miskimen, K., Gilmore, H., Dimitrova, N., Krasnitz, A., Harris, L., Wigler, M., Hicks, J. 2015 Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Research, 25: 714-724. PDF
. Garvin, T., Aboukhalil, R., Kendall, J., Baslan, T., Atwal, G.S., Hicks, J., Wigler, M., Schatz, M.C. 2015 Interactive analysis and quality assessment of single-cell coy-number variations. Nature Methods, 12: 1058-1060. doi:10.1038/nmeth.3578. PMID 263440432. PDF
. Mukhopadhyay, S., Wigler, M., Levy, D. 2015 Simple genetic models for autism spectrum disorder. BioRxiv/2015/017301. PDF
. Iossifov, I., Levy, D., Allen, J., Ye, K., Ronemus, M., Lee, Y-H., Yamrom, B., Wigler, M. 2015 Low load for disruptive mutations in autism genes and their biased transmission. Proc. Natl. Acad. Sci. USA., 112: E5600-7. PMCID: 4611648. PDF
. Baslan, T., Kendall, J., Rodgers, L., Cox, H., Riggs, M., Stepansky, A., Troge, J., Ravi, K., Esposito, D., Lakshmi, B., Wigler, M., Navin, N., Hicks J. 2016 Corrigendum: Genome-wide copy number analysis of single cells. Nature Protocols, 11: 616. PDF
. Wang, Z., Andrews, P., Kendall, J., Ma, B., Hakker, I., Rodgers, L., Ronemus, M., Wigler, M. and Levy, D. 2016 SMASH, a fragmentation and sequencing method for genomic copy number analysis. Genome Research, 26: 1-8. PDF
. Andrews, P.A., Iossifov, I., Kendall, J., Marks, S., Muthuswamy, L., Wang, Z., Levy, D. and Wigler, M. 2016 MUMdex: MUM-based structural variation detection. bioRxiv/2016/078261. PDF
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